Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | E3S80_RS05660 | Genome accession | NZ_CP047847 |
| Coordinates | 1087892..1088461 (+) | Length | 189 a.a. |
| NCBI ID | WP_000287265.1 | Uniprot ID | A0A7U7EXU5 |
| Organism | Staphylococcus aureus strain UP_522 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1051850..1087790 | 1087892..1088461 | flank | 102 |
Gene organization within MGE regions
Location: 1051850..1088461
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S80_RS05435 (E3S80_05435) | - | 1052540..1053694 (+) | 1155 | WP_000777579.1 | aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme | - |
| E3S80_RS05440 (E3S80_05440) | sspA | 1054222..1055232 (+) | 1011 | WP_031775067.1 | Glu-specific serine endopeptidase SspA | - |
| E3S80_RS05445 (E3S80_05445) | sspB | 1055314..1056495 (+) | 1182 | WP_001089097.1 | cysteine protease staphopain B | - |
| E3S80_RS05450 (E3S80_05450) | sspC | 1056533..1056862 (+) | 330 | WP_000284457.1 | staphostatin B | - |
| E3S80_RS05455 (E3S80_05455) | menB | 1057100..1057921 (-) | 822 | WP_000184947.1 | 1,4-dihydroxy-2-naphthoyl-CoA synthase | - |
| E3S80_RS05460 (E3S80_05460) | menH | 1057914..1058717 (-) | 804 | WP_000150199.1 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | - |
| E3S80_RS05465 (E3S80_05465) | menD | 1058704..1060377 (-) | 1674 | WP_000526680.1 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase | - |
| E3S80_RS05470 (E3S80_05470) | - | 1060364..1061698 (-) | 1335 | WP_223876854.1 | isochorismate synthase | - |
| E3S80_RS14205 (E3S80_05475) | - | 1061652..1061756 (-) | 105 | WP_001791731.1 | hypothetical protein | - |
| E3S80_RS05480 (E3S80_05480) | - | 1061907..1062845 (+) | 939 | WP_000070966.1 | 1,4-dihydroxy-2-naphthoate polyprenyltransferase | - |
| E3S80_RS05485 (E3S80_05485) | - | 1062897..1063448 (-) | 552 | WP_000620949.1 | GNAT family N-acetyltransferase | - |
| E3S80_RS05490 (E3S80_05490) | - | 1063613..1063828 (+) | 216 | WP_000867357.1 | TM2 domain-containing protein | - |
| E3S80_RS05495 (E3S80_05495) | - | 1063892..1064023 (+) | 132 | WP_001790177.1 | SAR1012 family small protein | - |
| E3S80_RS05500 (E3S80_05500) | - | 1064069..1065029 (-) | 961 | Protein_1065 | ABC transporter substrate-binding protein | - |
| E3S80_RS05505 (E3S80_05505) | - | 1065517..1065873 (+) | 357 | WP_000766009.1 | DoxX family protein | - |
| E3S80_RS05510 (E3S80_05510) | - | 1065962..1066099 (-) | 138 | WP_001792054.1 | poly(glycerol-phosphate) alpha-glucosyltransferase | - |
| E3S80_RS05515 (E3S80_05515) | - | 1066240..1066530 (+) | 291 | WP_001795266.1 | hypothetical protein | - |
| E3S80_RS05520 (E3S80_05520) | - | 1066618..1067259 (-) | 642 | WP_000571167.1 | ABC transporter ATP-binding protein | - |
| E3S80_RS05525 (E3S80_05525) | - | 1067256..1067576 (-) | 321 | WP_000668627.1 | YxeA family protein | - |
| E3S80_RS05530 (E3S80_05530) | - | 1067579..1068322 (-) | 744 | Protein_1071 | DUF1430 domain-containing protein | - |
| E3S80_RS05535 (E3S80_05535) | - | 1068542..1069078 (-) | 537 | WP_078056058.1 | IS30 family transposase | - |
| E3S80_RS05540 (E3S80_05540) | - | 1069059..1069562 (-) | 504 | WP_160199374.1 | helix-turn-helix domain-containing protein | - |
| E3S80_RS05545 (E3S80_05545) | - | 1069671..1070027 (-) | 357 | WP_001255379.1 | cystatin-like fold lipoprotein | - |
| E3S80_RS05550 (E3S80_05550) | - | 1070083..1070673 (-) | 591 | WP_000810443.1 | hypothetical protein | - |
| E3S80_RS05555 (E3S80_05555) | - | 1070680..1071726 (-) | 1047 | WP_160199375.1 | CHAP domain-containing protein | - |
| E3S80_RS05560 (E3S80_05560) | - | 1071716..1073563 (-) | 1848 | WP_000681154.1 | CD3337/EF1877 family mobilome membrane protein | - |
| E3S80_RS05565 (E3S80_05565) | - | 1073568..1074926 (-) | 1359 | WP_001251190.1 | FtsK/SpoIIIE domain-containing protein | - |
| E3S80_RS05570 (E3S80_05570) | - | 1074989..1075255 (-) | 267 | WP_000453449.1 | hypothetical protein | - |
| E3S80_RS05575 (E3S80_05575) | - | 1075493..1075969 (+) | 477 | WP_001031902.1 | hypothetical protein | - |
| E3S80_RS05580 (E3S80_05580) | - | 1076142..1078637 (-) | 2496 | WP_001049261.1 | ATP-binding protein | - |
| E3S80_RS05585 (E3S80_05585) | - | 1078672..1079055 (-) | 384 | WP_000358144.1 | TcpE family conjugal transfer membrane protein | - |
| E3S80_RS05590 (E3S80_05590) | - | 1079067..1079327 (-) | 261 | WP_000015639.1 | TcpD family membrane protein | - |
| E3S80_RS05595 (E3S80_05595) | - | 1079332..1080387 (-) | 1056 | WP_000692002.1 | conjugal transfer protein | - |
| E3S80_RS05600 (E3S80_05600) | - | 1080448..1081539 (-) | 1092 | WP_000173102.1 | replication initiation factor domain-containing protein | - |
| E3S80_RS05605 (E3S80_05605) | - | 1081714..1082016 (-) | 303 | WP_000386891.1 | hypothetical protein | - |
| E3S80_RS05610 (E3S80_05610) | - | 1082030..1082350 (-) | 321 | WP_000805734.1 | DUF961 family protein | - |
| E3S80_RS05615 (E3S80_05615) | - | 1082501..1082785 (-) | 285 | WP_000134542.1 | hypothetical protein | - |
| E3S80_RS05620 (E3S80_05620) | - | 1082839..1084062 (-) | 1224 | Protein_1089 | bacteriocin-associated integral membrane family protein | - |
| E3S80_RS05625 (E3S80_05625) | - | 1084106..1084378 (-) | 273 | WP_001797239.1 | lactococcin 972 family bacteriocin | - |
| E3S80_RS05630 (E3S80_05630) | - | 1084388..1084489 (-) | 102 | WP_031763719.1 | hypothetical protein | - |
| E3S80_RS14375 | - | 1085028..1085105 (-) | 78 | WP_099112139.1 | putative holin-like toxin | - |
| E3S80_RS05640 (E3S80_05640) | - | 1085405..1086007 (-) | 603 | WP_001033865.1 | type II CAAX prenyl endopeptidase Rce1 family protein | - |
| E3S80_RS05645 (E3S80_05645) | - | 1086022..1086198 (-) | 177 | WP_000214898.1 | YkvS family protein | - |
| E3S80_RS05650 (E3S80_05650) | - | 1086397..1087383 (+) | 987 | WP_000668818.1 | lipoate--protein ligase | - |
| E3S80_RS05655 (E3S80_05655) | - | 1087464..1087682 (-) | 219 | WP_000876826.1 | IDEAL domain-containing protein | - |
| E3S80_RS05660 (E3S80_05660) | comK/comK1 | 1087892..1088461 (+) | 570 | WP_000287265.1 | competence protein ComK | Regulator |
Sequence
Protein
Download Length: 189 a.a. Molecular weight: 22601.83 Da Isoelectric Point: 9.6091
>NTDB_id=417727 E3S80_RS05660 WP_000287265.1 1087892..1088461(+) (comK/comK1) [Staphylococcus aureus strain UP_522]
MYSQNIYVIRKGDMVIRPAFDDDDQRNGSEIIRFDKTRIQNPFKVQKIIERSCKFYGNTYLGKKAETNRITGISSKPPIL
LTPLFPTYFFPTHSDRQNENIWLNMHYIESIKELKNRKCKVTFINNESIILHVSYHSLWHQYNNSIFYYYMVDKQSRMIS
KNPDQPIDYNKATLNVFEALTRYSLFEDK
MYSQNIYVIRKGDMVIRPAFDDDDQRNGSEIIRFDKTRIQNPFKVQKIIERSCKFYGNTYLGKKAETNRITGISSKPPIL
LTPLFPTYFFPTHSDRQNENIWLNMHYIESIKELKNRKCKVTFINNESIILHVSYHSLWHQYNNSIFYYYMVDKQSRMIS
KNPDQPIDYNKATLNVFEALTRYSLFEDK
Nucleotide
Download Length: 570 bp
>NTDB_id=417727 E3S80_RS05660 WP_000287265.1 1087892..1088461(+) (comK/comK1) [Staphylococcus aureus strain UP_522]
ATGTATTCTCAAAATATTTATGTGATACGCAAAGGAGACATGGTTATTCGACCAGCATTTGATGATGACGATCAAAGAAA
CGGTAGTGAAATAATTCGGTTTGACAAAACGCGTATTCAAAATCCTTTTAAAGTCCAGAAAATCATTGAACGCTCTTGCA
AATTTTATGGTAATACTTATCTTGGCAAGAAAGCAGAGACAAACCGCATTACTGGCATTTCTAGTAAACCACCTATTTTA
CTAACACCATTATTTCCAACTTATTTTTTCCCAACACATTCTGACAGACAAAATGAAAATATTTGGTTAAATATGCATTA
TATCGAAAGTATTAAAGAATTAAAAAATCGTAAATGTAAAGTGACATTTATTAATAATGAATCTATCATTCTTCATGTTT
CATACCACAGTTTATGGCATCAATATAACAATTCCATTTTTTACTATTACATGGTAGATAAACAATCTCGCATGATATCA
AAAAATCCCGACCAACCAATAGATTATAATAAAGCCACATTGAATGTGTTTGAAGCATTGACACGCTATTCTTTATTTGA
AGATAAATAA
ATGTATTCTCAAAATATTTATGTGATACGCAAAGGAGACATGGTTATTCGACCAGCATTTGATGATGACGATCAAAGAAA
CGGTAGTGAAATAATTCGGTTTGACAAAACGCGTATTCAAAATCCTTTTAAAGTCCAGAAAATCATTGAACGCTCTTGCA
AATTTTATGGTAATACTTATCTTGGCAAGAAAGCAGAGACAAACCGCATTACTGGCATTTCTAGTAAACCACCTATTTTA
CTAACACCATTATTTCCAACTTATTTTTTCCCAACACATTCTGACAGACAAAATGAAAATATTTGGTTAAATATGCATTA
TATCGAAAGTATTAAAGAATTAAAAAATCGTAAATGTAAAGTGACATTTATTAATAATGAATCTATCATTCTTCATGTTT
CATACCACAGTTTATGGCATCAATATAACAATTCCATTTTTTACTATTACATGGTAGATAAACAATCTCGCATGATATCA
AAAAATCCCGACCAACCAATAGATTATAATAAAGCCACATTGAATGTGTTTGAAGCATTGACACGCTATTCTTTATTTGA
AGATAAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
100 |
100 |
1 |
| comK/comK1 | Staphylococcus aureus N315 |
100 |
100 |
1 |