Detailed information NTG0417535

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S85_RS00440
• Genome accession: NZ_CP047839
• Coordinates: 81511..82554 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_678
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76511..87554

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S85_RS00410 (E3S85_00410)	-	76954..77064 (+)	111	WP_001790257.1	hypothetical protein	-
E3S85_RS00415 (E3S85_00415)	-	77093..77506 (+)	414	WP_001643743.1	hypothetical protein	-
E3S85_RS00420 (E3S85_00420)	-	77695..78681 (-)	987	WP_001014423.1	FUSC family protein	-
E3S85_RS00425 (E3S85_00425)	map	79437..80195 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S85_RS00430 (E3S85_00430)	-	80412..80798 (+)	387	WP_001110178.1	hypothetical protein	-
E3S85_RS00435 (E3S85_00435)	liaF	80813..81514 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S85_RS00440 (E3S85_00440)	vraS	81511..82554 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S85_RS00445 (E3S85_00445)	vraR	82544..83173 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S85_RS00450 (E3S85_00450)	-	83286..84503 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
E3S85_RS00455 (E3S85_00455)	-	84781..85056 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S85_RS00460 (E3S85_00460)	-	85063..85527 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
E3S85_RS00465 (E3S85_00465)	-	85674..85874 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3S85_RS00470 (E3S85_00470)	-	85877..87133 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417535 E3S85_RS00440 WP_001017131.1 81511..82554(+) (vraS) [Staphylococcus aureus strain UP_678]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417535 E3S85_RS00440 WP_001017131.1 81511..82554(+) (vraS) [Staphylococcus aureus strain UP_678]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1