Detailed information NTG0416610

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S75_RS00445
• Genome accession: NZ_CP047798
• Coordinates: 81137..82180 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_378
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76137..87180

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S75_RS00415 (E3S75_00415)	-	76714..76823 (+)	110	Protein_84	hypothetical protein	-
E3S75_RS00420 (E3S75_00420)	-	76852..77265 (+)	414	WP_001622129.1	hypothetical protein	-
E3S75_RS00425 (E3S75_00425)	-	77443..78429 (-)	987	WP_000999713.1	FUSC family protein	-
E3S75_RS00430 (E3S75_00430)	map	79063..79821 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
E3S75_RS00435 (E3S75_00435)	-	80038..80424 (+)	387	WP_001110184.1	hypothetical protein	-
E3S75_RS00440 (E3S75_00440)	liaF	80439..81140 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S75_RS00445 (E3S75_00445)	vraS	81137..82180 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S75_RS00450 (E3S75_00450)	vraR	82170..82799 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S75_RS00455 (E3S75_00455)	-	82912..84129 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
E3S75_RS00460 (E3S75_00460)	-	84407..84682 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S75_RS00465 (E3S75_00465)	-	84689..85153 (-)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
E3S75_RS00470 (E3S75_00470)	-	85300..85500 (+)	201	WP_000180459.1	DUF1128 family protein	-
E3S75_RS00475 (E3S75_00475)	-	85569..86759 (+)	1191	WP_411896787.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=416610 E3S75_RS00445 WP_001017131.1 81137..82180(+) (vraS) [Staphylococcus aureus strain UP_378]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=416610 E3S75_RS00445 WP_001017131.1 81137..82180(+) (vraS) [Staphylococcus aureus strain UP_378]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1