Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   H7795_RS02755 Genome accession   NZ_CP060641
Coordinates   524490..525131 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain TSPY210     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 519490..530131
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7795_RS02735 (H7795_02725) - 520046..520786 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  H7795_RS02740 (H7795_02730) pknB 520783..522681 (+) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H7795_RS02745 (H7795_02735) liaF 522804..523496 (+) 693 WP_023612959.1 cell wall-active antibiotics response protein LiaF -
  H7795_RS02750 (H7795_02740) - 523493..524497 (+) 1005 WP_002991890.1 sensor histidine kinase -
  H7795_RS02755 (H7795_02745) vraR 524490..525131 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  H7795_RS02760 (H7795_02750) - 525168..526568 (+) 1401 WP_023612963.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  H7795_RS02765 (H7795_02755) - 526568..526945 (+) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  H7795_RS02770 (H7795_02760) cysK 526964..527905 (-) 942 WP_011888673.1 cysteine synthase A -
  H7795_RS02775 (H7795_02765) - 528033..528665 (-) 633 WP_009880468.1 YigZ family protein -
  H7795_RS02780 (H7795_02770) comFA/cflA 528721..530046 (+) 1326 WP_063629559.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=415780 H7795_RS02755 WP_002983671.1 524490..525131(+) (vraR) [Streptococcus pyogenes strain TSPY210]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=415780 H7795_RS02755 WP_002983671.1 524490..525131(+) (vraR) [Streptococcus pyogenes strain TSPY210]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTGCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385