Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   H7797_RS07130 Genome accession   NZ_CP060639
Coordinates   1423547..1424188 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain TSPY153     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1418547..1429188
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7797_RS07105 (H7797_07075) comFA/cflA 1418634..1419959 (-) 1326 WP_110002775.1 DEAD/DEAH box helicase Machinery gene
  H7797_RS07110 (H7797_07080) - 1420014..1420646 (+) 633 WP_228636931.1 YigZ family protein -
  H7797_RS07115 (H7797_07085) cysK 1420774..1421715 (+) 942 WP_010922535.1 cysteine synthase A -
  H7797_RS07120 (H7797_07090) - 1421733..1422110 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  H7797_RS07125 (H7797_07095) - 1422110..1423510 (-) 1401 WP_023079249.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  H7797_RS07130 (H7797_07100) vraR 1423547..1424188 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  H7797_RS07135 (H7797_07105) - 1424181..1425185 (-) 1005 WP_002991890.1 sensor histidine kinase -
  H7797_RS07140 (H7797_07110) liaF 1425182..1425874 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  H7797_RS07145 (H7797_07115) pknB 1425997..1427895 (-) 1899 WP_109991562.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H7797_RS07150 (H7797_07120) - 1427892..1428632 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=415617 H7797_RS07130 WP_002983671.1 1423547..1424188(-) (vraR) [Streptococcus pyogenes strain TSPY153]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=415617 H7797_RS07130 WP_002983671.1 1423547..1424188(-) (vraR) [Streptococcus pyogenes strain TSPY153]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment