Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   H6X75_RS02010 Genome accession   NZ_CP060156
Coordinates   380535..381167 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain PZ900700608     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 375535..386167
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H6X75_RS01985 (H6X75_01950) mvaD 375812..376765 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  H6X75_RS01990 (H6X75_01955) - 376752..377759 (+) 1008 WP_000562428.1 phosphomevalonate kinase -
  H6X75_RS01995 (H6X75_01960) fni 377743..378753 (+) 1011 WP_000210620.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  H6X75_RS02000 (H6X75_01965) liaF 378831..379529 (+) 699 WP_001224640.1 cell wall-active antibiotics response protein LiaF -
  H6X75_RS02005 (H6X75_01970) - 379526..380521 (+) 996 WP_000743669.1 sensor histidine kinase -
  H6X75_RS02010 (H6X75_01975) vraR 380535..381167 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  H6X75_RS02015 - 381243..381926 (+) 684 Protein_396 DNA alkylation repair protein -
  H6X75_RS02020 (H6X75_01995) - 382076..382315 (+) 240 WP_000754502.1 hypothetical protein -
  H6X75_RS02025 (H6X75_02000) cbpG 382396..382986 (+) 591 Protein_398 choline-binding protein CbpG -
  H6X75_RS02030 (H6X75_02005) - 383288..383647 (+) 360 WP_000378120.1 tyrosine-type recombinase/integrase -
  H6X75_RS02035 (H6X75_02010) tig 383841..385124 (+) 1284 WP_000116465.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=413485 H6X75_RS02010 WP_000698434.1 380535..381167(+) (vraR) [Streptococcus pneumoniae strain PZ900700608]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=413485 H6X75_RS02010 WP_000698434.1 380535..381167(+) (vraR) [Streptococcus pneumoniae strain PZ900700608]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAACATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41