Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   GO596_RS05490 Genome accession   NZ_CP046628
Coordinates   1094138..1095490 (+) Length   450 a.a.
NCBI ID   WP_024343735.1    Uniprot ID   -
Organism   Streptococcus equinus strain CNU 77-23     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1095230..1121814 1094138..1095490 flank -260


Gene organization within MGE regions


Location: 1094138..1121814
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GO596_RS05490 (GO596_05490) vicK 1094138..1095490 (+) 1353 WP_024343735.1 cell wall metabolism sensor histidine kinase VicK Regulator
  GO596_RS05495 (GO596_05495) vicX 1095491..1096300 (+) 810 WP_157339348.1 MBL fold metallo-hydrolase Regulator
  GO596_RS05505 (GO596_05505) - 1096676..1096990 (+) 315 WP_000420682.1 YdcP family protein -
  GO596_RS05510 (GO596_05510) - 1097006..1097392 (+) 387 WP_157339349.1 YdcP family protein -
  GO596_RS05515 (GO596_05515) - 1097421..1098806 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  GO596_RS05520 (GO596_05520) - 1098809..1098961 (+) 153 WP_000879507.1 hypothetical protein -
  GO596_RS05525 (GO596_05525) mobT 1098984..1100189 (+) 1206 WP_000398284.1 MobT family relaxase -
  GO596_RS05530 (GO596_05530) - 1100232..1100453 (+) 222 WP_001009056.1 hypothetical protein -
  GO596_RS05535 (GO596_05535) - 1100570..1101067 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  GO596_RS05540 (GO596_05540) - 1101156..1101548 (+) 393 WP_000723888.1 conjugal transfer protein -
  GO596_RS05545 (GO596_05545) - 1101532..1103979 (+) 2448 WP_000331160.1 ATP-binding protein -
  GO596_RS05550 (GO596_05550) - 1103982..1106159 (+) 2178 WP_000804748.1 CD3337/EF1877 family mobilome membrane protein -
  GO596_RS05555 (GO596_05555) - 1106156..1107157 (+) 1002 WP_000769868.1 lysozyme family protein -
  GO596_RS05560 (GO596_05560) - 1107154..1108086 (+) 933 WP_157339350.1 conjugal transfer protein -
  GO596_RS09540 - 1108400..1108447 (+) 48 Protein_1026 hypothetical protein -
  GO596_RS05570 (GO596_05570) tet(M) 1108463..1110382 (+) 1920 WP_157339351.1 tetracycline resistance ribosomal protection protein Tet(M) -
  GO596_RS05575 (GO596_05575) - 1110501..1110668 (+) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  GO596_RS05580 (GO596_05580) - 1110728..1111081 (-) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  GO596_RS05590 (GO596_05590) - 1111586..1112008 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  GO596_RS05595 (GO596_05595) - 1112005..1112235 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  GO596_RS09480 (GO596_05600) - 1112461..1112712 (-) 252 WP_001845478.1 hypothetical protein -
  GO596_RS05605 (GO596_05605) - 1112696..1112899 (+) 204 WP_000814511.1 excisionase -
  GO596_RS05610 (GO596_05610) - 1112981..1114198 (+) 1218 WP_157339352.1 tyrosine-type recombinase/integrase -
  GO596_RS05615 (GO596_05615) rnc 1114548..1115234 (+) 687 WP_021142842.1 ribonuclease III -
  GO596_RS05620 (GO596_05620) smc 1115381..1118920 (+) 3540 WP_157339353.1 chromosome segregation protein SMC -
  GO596_RS05625 (GO596_05625) - 1118961..1119770 (-) 810 WP_157339354.1 DUF6287 domain-containing protein -
  GO596_RS05630 (GO596_05630) - 1119946..1120743 (+) 798 WP_074533596.1 Cof-type HAD-IIB family hydrolase -
  GO596_RS05635 (GO596_05635) - 1120743..1121564 (+) 822 WP_021142837.1 Cof-type HAD-IIB family hydrolase -

Sequence

Protein


Download         Length: 450 a.a.        Molecular weight: 51391.34 Da        Isoelectric Point: 4.7300

>NTDB_id=406249 GO596_RS05490 WP_024343735.1 1094138..1095490(+) (vicK) [Streptococcus equinus strain CNU 77-23]
MNNIMSQNQYLFEQAILFLLAFVAVYFIHLAIRDYRTSVNIRRLSGKVRELITGKYTEDIIIEKDRDLAELAGQLNDLST
VFRLAQENLAQEKNRLASILSYMTDGVLATDRSGNITMINQTAQQQLNLEREEALGMNIVDILGDDSDYTYHDLVSKTPE
IVLNRRDETGEFITLRIRFALNRRDSGFISGLIAVLHDTTEQEKEDRERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMIRMISDLLNLSRIDNQTVQLEVEMTNFTAFMTSILNRFDQIKSQHTVAGKQYEIVRDYPIKS
IWLEIDPDKMTQVLDNILNNAIKYSPDGGKITVSMKTTETQLIISISDEGLGIPKKDLPLIFDRFYRVDKARSRAQGGSG
LGLAIAKEIVKQHKGFIWAQSTYGKGSTFTIVLPYEKDSDIYDEWEDDED

Nucleotide


Download         Length: 1353 bp        

>NTDB_id=406249 GO596_RS05490 WP_024343735.1 1094138..1095490(+) (vicK) [Streptococcus equinus strain CNU 77-23]
ATGAATAATATAATGTCACAGAATCAGTATCTGTTTGAGCAGGCAATCTTGTTTTTGCTCGCTTTTGTCGCTGTTTACTT
TATTCATTTAGCGATAAGAGATTATCGAACTTCAGTTAATATTCGTCGTTTGAGTGGTAAGGTTCGTGAGCTTATCACTG
GTAAATATACTGAAGATATCATTATCGAAAAAGATAGAGATTTGGCTGAACTTGCTGGTCAGTTAAATGACTTGTCAACG
GTTTTTCGCTTGGCTCAGGAAAATCTTGCGCAGGAAAAAAATCGTTTGGCTAGTATTTTGTCTTACATGACTGATGGTGT
CTTGGCTACTGACCGTTCTGGAAATATCACCATGATTAACCAGACAGCTCAGCAGCAACTTAATCTGGAACGCGAAGAAG
CTCTTGGAATGAATATTGTTGATATTCTTGGGGACGATAGCGATTATACCTACCATGATTTGGTTTCTAAGACACCTGAG
ATTGTTCTAAATCGCCGTGATGAGACAGGTGAATTTATCACTTTGCGAATTCGTTTTGCGCTAAATCGTCGTGATAGTGG
CTTTATCTCAGGGTTGATTGCTGTTTTACATGATACAACGGAACAGGAAAAAGAAGACCGAGAACGTCGTTTATTCGTAT
CAAATGTTAGTCACGAATTGCGTACACCGTTGACATCTGTGAAATCATATTTGGAAGCTTTGGATGAAGGTGCCCTTAAA
GAAGATATTGCACCAAGTTTTATTAAAGTTTCTCTTGATGAAACAAACCGCATGATTCGAATGATTTCTGATTTGCTCAA
TTTGTCTCGAATTGATAATCAGACTGTTCAGCTTGAAGTTGAAATGACTAACTTTACAGCATTTATGACATCAATTTTGA
ACCGTTTTGACCAAATTAAGAGTCAACATACTGTCGCTGGTAAGCAGTACGAGATTGTCAGAGATTATCCAATCAAATCT
ATCTGGTTAGAAATTGACCCAGATAAAATGACGCAAGTTCTGGATAATATCCTTAATAATGCAATTAAGTATTCGCCAGA
TGGTGGTAAAATCACTGTCAGCATGAAGACGACTGAGACACAGTTGATTATTTCAATTTCTGATGAAGGTCTTGGTATTC
CTAAGAAAGATTTGCCACTAATCTTTGACCGATTCTATCGTGTTGACAAGGCTAGAAGTCGTGCTCAAGGTGGTTCAGGA
CTTGGTCTTGCGATTGCAAAAGAAATTGTTAAACAACACAAAGGATTTATTTGGGCTCAAAGTACTTATGGAAAAGGCTC
AACCTTTACAATTGTTCTTCCGTATGAGAAGGATTCTGATATTTATGACGAATGGGAGGATGACGAGGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(95-189)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(326-436)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

76.867

92.222

0.709
  micB Streptococcus pneumoniae Cp1015

66.038

94.222

0.622

Multiple sequence alignment