Detailed information    

insolico Bioinformatically predicted

Overview


Name   comC/comC2   Type   Regulator
Locus tag   GL184_RS00040 Genome accession   NZ_CP046356
Coordinates   5894..6019 (+) Length   41 a.a.
NCBI ID   WP_000799694.1    Uniprot ID   Q9WW44
Organism   Streptococcus pneumoniae strain 521     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context


Location: 894..11019
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL184_RS00015 (GL184_00015) dnaA 1379..2740 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  GL184_RS00020 (GL184_00020) spo0J 2953..3711 (-) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  GL184_RS00025 (GL184_00025) htrA 3769..4950 (-) 1182 WP_000681598.1 S1C family serine protease Regulator
  GL184_RS00030 (GL184_00030) rlmH 5133..5612 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GL184_RS00040 (GL184_00040) comC/comC2 5894..6019 (+) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  GL184_RS00045 (GL184_00045) comD/comD2 6040..7365 (+) 1326 WP_024477997.1 competence system sensor histidine kinase ComD Regulator
  GL184_RS00050 (GL184_00050) comE 7362..8114 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  GL184_RS00065 (GL184_00065) - 8357..8899 (-) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  GL184_RS11480 - 9078..10681 (+) 1604 Protein_10 YhgE/Pip family protein -

Sequence


Protein


Download         Length: 41 a.a.        Molecular weight: 4892.93 Da        Isoelectric Point: 10.9061

>NTDB_id=403074 GL184_RS00040 WP_000799694.1 5894..6019(+) (comC/comC2) [Streptococcus pneumoniae strain 521]
MKNTVKLEQFVALKEKDLQNIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=403074 GL184_RS00040 WP_000799694.1 5894..6019(+) (comC/comC2) [Streptococcus pneumoniae strain 521]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAATATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains


Predicted by InterproScan.

(1-29)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB Q9WW44

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

97.561

100

0.976

  comC/comC2 Streptococcus pneumoniae TIGR4

97.561

100

0.976

  comC/comC1 Streptococcus pneumoniae R6

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae G54

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae D39

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae Rx1

78.049

100

0.78

  comC Streptococcus mitis SK321

75.61

100

0.756

  comC Streptococcus mitis NCTC 12261

60

97.561

0.585


Multiple sequence alignment