Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   GL183_RS00045 Genome accession   NZ_CP046355
Coordinates   6166..7491 (+) Length   441 a.a.
NCBI ID   WP_024477997.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 475     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1166..12491
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL183_RS00015 (GL183_00015) dnaA 1505..2866 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  GL183_RS00020 (GL183_00020) spo0J 3079..3837 (-) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  GL183_RS00025 (GL183_00025) htrA 3895..5076 (-) 1182 WP_000681598.1 S1C family serine protease Regulator
  GL183_RS00030 (GL183_00030) rlmH 5259..5738 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GL183_RS00040 (GL183_00040) comC/comC2 6020..6145 (+) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  GL183_RS00045 (GL183_00045) comD/comD2 6166..7491 (+) 1326 WP_024477997.1 competence system sensor histidine kinase ComD Regulator
  GL183_RS00050 (GL183_00050) comE 7488..8240 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  GL183_RS00065 (GL183_00065) - 8483..9025 (-) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  GL183_RS11765 - 9204..10807 (+) 1604 Protein_10 YhgE/Pip domain-containing protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51489.09 Da        Isoelectric Point: 7.5816

>NTDB_id=402997 GL183_RS00045 WP_024477997.1 6166..7491(+) (comD/comD2) [Streptococcus pneumoniae strain 475]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYIFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYFYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=402997 GL183_RS00045 WP_024477997.1 6166..7491(+) (comD/comD2) [Streptococcus pneumoniae strain 475]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACATTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACTTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.093

100

0.991
  comD/comD1 Streptococcus pneumoniae Rx1

96.372

100

0.964
  comD/comD1 Streptococcus pneumoniae D39

96.372

100

0.964
  comD/comD1 Streptococcus pneumoniae R6

96.372

100

0.964
  comD Streptococcus mitis SK321

91.61

100

0.916
  comD Streptococcus mitis NCTC 12261

86.395

100

0.864
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419

Multiple sequence alignment