Detailed information NTG0402252

Bioinformatically predicted

Overview

• Name: disA
• Type: Machinery gene
• Locus tag: HUT14_RS19085
• Genome accession: NZ_CP054939
• Coordinates: 4213013..4214137 (-)
• Length: 374 a.a.
• NCBI ID: WP_004928018.1
• Uniprot ID: D9Y062
• Organism: Streptomyces sp. NA02536
• Function: homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 4208013..4219137

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HUT14_RS19065 (HUT14_19075)	-	4209014..4210597 (+)	1584	WP_176117893.1	sensor histidine kinase	-
HUT14_RS19070 (HUT14_19080)	-	4210594..4211259 (+)	666	WP_121546964.1	response regulator transcription factor	-
HUT14_RS19075 (HUT14_19085)	-	4211266..4211919 (-)	654	WP_176117894.1	phosphatase PAP2 family protein	-
HUT14_RS19080 (HUT14_19090)	-	4212094..4212969 (+)	876	WP_121546966.1	hypothetical protein	-
HUT14_RS19085 (HUT14_19095)	disA	4213013..4214137 (-)	1125	WP_004928018.1	DNA integrity scanning diadenylate cyclase DisA	Machinery gene
HUT14_RS19090 (HUT14_19100)	radA	4214204..4215613 (-)	1410	WP_176117895.1	DNA repair protein RadA	Machinery gene
HUT14_RS19095 (HUT14_19105)	-	4215799..4217571 (+)	1773	WP_176117896.1	sigma-70 family RNA polymerase sigma factor	-
HUT14_RS19100 (HUT14_19110)	-	4217598..4218482 (-)	885	WP_176117897.1	hypothetical protein	-

Sequence

Protein

• Length: 374 a.a.
• Molecular weight: 40151.90 Da
• Isoelectric Point: 5.2111

>NTDB_id=402252 HUT14_RS19085 WP_004928018.1 4213013..4214137(-) (disA) [Streptomyces sp. NA02536]
MAANDRAGAPGKSGGSAGSDGLMRASLSAVAPGTHLRDGLERVLRGNTGGLIVLGFDKTVETLCSGGFVLDVEFTATRLR
ELCKLDGGIVLSSDLSKILRAGVQLVPDPTIPTEETGTRHRTADRVSKQVGFPVVSVSQSMRLIALYVDGHRRVLEDSAA
ILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVSAVAQRLEMVRRIATEIAEYVVELGTDGRLLALQLDELIA
GVEPERELVVRDYVPEPTAKRSRTVDEALHELNALPQAELLELPTVARALGYTGSPETLDSAVSPRGFRLLAKVPRLPGA
IIDRLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV

Nucleotide

• Length: 1125 bp

>NTDB_id=402252 HUT14_RS19085 WP_004928018.1 4213013..4214137(-) (disA) [Streptomyces sp. NA02536]
GTGGCAGCCAACGACCGGGCAGGAGCTCCCGGAAAGTCCGGTGGGAGTGCCGGTTCCGATGGCCTGATGCGCGCCTCGCT
GAGCGCCGTGGCACCCGGCACCCATCTCCGTGACGGCCTGGAGCGCGTGCTCCGCGGCAACACCGGCGGCCTCATCGTCC
TCGGATTCGACAAGACCGTCGAGACGCTCTGCAGCGGCGGTTTCGTGCTGGACGTCGAGTTCACCGCGACCCGGCTGCGC
GAACTGTGCAAGCTGGACGGCGGCATCGTCCTGTCGTCCGACCTGTCCAAGATCCTGCGGGCCGGCGTCCAGCTGGTGCC
GGACCCCACCATCCCCACCGAGGAGACCGGCACCCGGCACCGCACCGCCGACCGCGTCTCCAAGCAGGTCGGCTTCCCCG
TCGTCTCGGTGTCGCAGTCGATGCGCCTGATCGCGCTGTACGTCGACGGCCACCGCCGGGTCCTGGAGGACTCGGCGGCG
ATCCTGTCCCGTGCCAACCAGGCGCTGGCCACCCTGGAGCGCTACAAGCTCCGCCTCGACGAGGTGGCCGGCACGCTGTC
GGCGCTGGAGATCGAGGACCTGGTGACCGTCCGGGACGTCTCCGCGGTCGCGCAGCGGCTGGAGATGGTGCGCCGCATCG
CCACCGAAATCGCCGAATACGTGGTCGAACTGGGCACCGACGGCCGTCTCCTCGCCCTCCAGCTCGACGAGTTGATCGCG
GGCGTGGAGCCGGAGCGCGAGCTGGTCGTGCGGGACTACGTGCCCGAGCCCACCGCCAAGCGCTCCCGCACGGTCGACGA
GGCCCTGCACGAACTGAACGCGCTCCCCCAGGCGGAGCTCCTGGAACTGCCGACGGTCGCCCGCGCCCTGGGCTACACCG
GCTCACCGGAGACGCTGGACTCCGCGGTGTCCCCGCGCGGCTTCCGCCTGCTGGCGAAGGTGCCGAGGCTGCCGGGCGCG
ATCATCGACCGGCTGGTGGAGCACTTCGGCGGGCTGCAGAAGCTGCTCGCCGCCAGTGTGGACGATCTGCAGACGGTGGA
CGGGGTCGGCGAGGCGCGGGCGCGCAGCGTGCGCGAGGGGCTGTCCCGCCTGGCGGAGAGCTCGATCCTCGAGCGGTACG
TCTAG

Domains

Predicted by InterProScan.

• DisA bacterial checkpoint controller nucleotide-binding (DAC) (38-151)

• Helix-hairpin-helix motif (HHH_2) (324-359)

• DisA bacterial checkpoint controller linker region (DisA-linker) (155-297)

3D structure

• AlphaFold DB: D9Y062

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
disA	Bacillus subtilis subsp. subtilis str. 168	46.821	92.513	0.433