Detailed information NTG0399421

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: GJE16_RS08365
• Genome accession: NZ_CP045931
• Coordinates: 1656193..1656852 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain AUSMDU00010538
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1651193..1661852

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GJE16_RS08340 (GJE16_08340)	-	1651498..1651815 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
GJE16_RS08345 (GJE16_08345)	-	1651830..1652726 (-)	897	WP_000825668.1	PEP phosphonomutase	-
GJE16_RS08350 (GJE16_08350)	-	1652729..1653991 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
GJE16_RS08355 (GJE16_08355)	-	1654271..1655449 (+)	1179	WP_000175879.1	ROK family transcriptional regulator	-
GJE16_RS08360 (GJE16_08360)	-	1655677..1656123 (-)	447	WP_050968605.1	GNAT family N-acetyltransferase	-
GJE16_RS08365 (GJE16_08365)	cclA/cilC	1656193..1656852 (+)	660	WP_000565017.1	prepilin peptidase	Machinery gene
GJE16_RS08370 (GJE16_08370)	-	1656904..1658055 (-)	1152	WP_000481749.1	helix-turn-helix domain-containing protein	-
GJE16_RS08375 (GJE16_08375)	-	1658070..1658801 (-)	732	WP_000934017.1	hypothetical protein	-
GJE16_RS08380 (GJE16_08380)	-	1659027..1659131 (+)	105	Protein_1646	prepilin peptidase	-
GJE16_RS08385 (GJE16_08385)	trpA	1659103..1659879 (-)	777	WP_001126997.1	tryptophan synthase subunit alpha	-
GJE16_RS08390 (GJE16_08390)	trpB	1659872..1661095 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
GJE16_RS08395 (GJE16_08395)	-	1661073..1661672 (-)	600	WP_000169892.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=399421 GJE16_RS08365 WP_000565017.1 1656193..1656852(+) (cclA/cilC) [Streptococcus pneumoniae strain AUSMDU00010538]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=399421 GJE16_RS08365 WP_000565017.1 1656193..1656852(+) (cclA/cilC) [Streptococcus pneumoniae strain AUSMDU00010538]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858