Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   HRS04_RS12575 Genome accession   NZ_CP054169
Coordinates   2390732..2391388 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain STO_Bone1B     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2385732..2396388
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HRS04_RS12545 (HRS04_12410) yecA 2386983..2387648 (-) 666 WP_000847880.1 UPF0149 family protein YecA -
  HRS04_RS12565 (HRS04_12430) pgsA 2388298..2388846 (-) 549 WP_074500281.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  HRS04_RS12570 (HRS04_12435) uvrC 2388903..2390735 (-) 1833 WP_001283424.1 excinuclease ABC subunit UvrC Machinery gene
  HRS04_RS12575 (HRS04_12440) letA 2390732..2391388 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  HRS04_RS24315 - 2391530..2391601 (+) 72 Protein_2278 transcriptional regulator -
  HRS04_RS12580 (HRS04_12445) yecU 2391684..2391860 (+) 177 WP_001307856.1 protein YecU -
  HRS04_RS12585 (HRS04_12450) yecF 2391847..2392071 (+) 225 WP_000106474.1 DUF2594 family protein YecF -
  HRS04_RS12590 (HRS04_12455) sdiA 2392138..2392860 (-) 723 WP_087760829.1 transcriptional regulator SdiA -
  HRS04_RS12595 (HRS04_12460) tcyN 2393090..2393842 (-) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  HRS04_RS12600 (HRS04_12465) tcyL 2393839..2394507 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  HRS04_RS12605 (HRS04_12470) dcyD 2394522..2395508 (-) 987 WP_001128215.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=397693 HRS04_RS12575 WP_000611328.1 2390732..2391388(-) (letA) [Escherichia coli strain STO_Bone1B]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=397693 HRS04_RS12575 WP_000611328.1 2390732..2391388(-) (letA) [Escherichia coli strain STO_Bone1B]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482