Detailed information NTG0038291

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: SP670_RS06760
• Genome accession: NC_014498
• Coordinates: 1282198..1284438 (-)
• Length: 746 a.a.
• NCBI ID: WP_000942383.1
• Uniprot ID: A0A0T8TEA1
• Organism: Streptococcus pneumoniae 670-6B
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1277198..1289438

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP670_RS06725 (SP670_1357)	-	1278100..1278480 (-)	381	WP_000157154.1	VOC family protein	-
SP670_RS06730 (SP670_1358)	rplT	1278538..1278897 (-)	360	WP_000124836.1	50S ribosomal protein L20	-
SP670_RS06735 (SP670_1359)	rpmI	1278949..1279149 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
SP670_RS06740 (SP670_1360)	infC	1279182..1279712 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
SP670_RS06745 (SP670_1362)	-	1280033..1281208 (-)	1176	WP_000655944.1	hypothetical protein	-
SP670_RS06750 (SP670_1363)	-	1281212..1281799 (-)	588	WP_000939880.1	ATP-binding cassette domain-containing protein	-
SP670_RS14635	-	1281832..1282049 (-)	218	Protein_1305	hypothetical protein	-
SP670_RS06760 (SP670_1364)	comEC/celB	1282198..1284438 (-)	2241	WP_000942383.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SP670_RS06765 (SP670_1365)	comEA/celA/cilE	1284422..1285072 (-)	651	WP_000387330.1	ComEA family DNA-binding protein	Machinery gene
SP670_RS06770 (SP670_1366)	-	1285140..1285709 (-)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
SP670_RS14255 (SP670_1369)	ald	1285886..1286997 (+)	1112	Protein_1309	alanine dehydrogenase	-
SP670_RS13535	-	1287298..1287623 (-)	326	Protein_1310	TfoX/Sxy family protein	-
SP670_RS06795 (SP670_1371)	-	1287626..1288126 (-)	501	WP_000566989.1	GNAT family N-acetyltransferase	-
SP670_RS06800 (SP670_1373)	-	1288319..1289287 (-)	969	WP_000658181.1	PhoH family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84620.31 Da
• Isoelectric Point: 9.8066

>NTDB_id=38291 SP670_RS06760 WP_000942383.1 1282198..1284438(-) (comEC/celB) [Streptococcus pneumoniae 670-6B]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFFQFPWKSASKVLVICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKRIQSLQKVGSWDIGEKLSSLRRKAVVWIKMHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTIKEGKGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNEWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEVTKAFHVGEILVSKGSLKQKQFVVELQATKTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=38291 SP670_RS06760 WP_000942383.1 1282198..1284438(-) (comEC/celB) [Streptococcus pneumoniae 670-6B]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTGTTACTTTGGCTTTACTACGCTATTTT
CTCAGCATCCTATCTTGCTTTGTTGGGATTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTA
GCAAAGTTCTAGTGATTTGTGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTCAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACACTCAATATTAAAAGAATCCAGTCACTCCAAAAGGTTGGCAGTTGGGATATAGG
TGAAAAACTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGATGCACTTCCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTAGGACATCTGGACACCGATTTTGAGGAGATGAATGAGCTTTATTCCAGTTTAGGAATTATTCACCTT
TTTGCCTTGTCAGGTATGCAGGTAGGGTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCATTAAAGAAGG
GAAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCCTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
CTCACAGGTGACAAGTAGGCCTCTAGTCTTTGGACAACCCAATGAATGGCTTTTAATCCTATTGTTAATTTCTTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCTTGACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTAAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGCCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (30-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

3D structure

• AlphaFold DB: A0A0T8TEA1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	97.051	100	0.971
comEC/celB	Streptococcus pneumoniae Rx1	96.247	100	0.962
comEC/celB	Streptococcus pneumoniae D39	96.247	100	0.962
comEC/celB	Streptococcus pneumoniae R6	96.247	100	0.962
comEC/celB	Streptococcus mitis SK321	91.689	100	0.917
comEC/celB	Streptococcus mitis NCTC 12261	91.544	99.866	0.914
comEC	Lactococcus lactis subsp. cremoris KW2	44.669	99.33	0.444