Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | HMPREF0837_RS10590 | Genome accession | NC_014251 |
| Coordinates | 2002782..2003402 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae TCH8431/19A | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1991237..2035155 | 2002782..2003402 | within | 0 |
Gene organization within MGE regions
Location: 1991237..2035155
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HMPREF0837_RS10520 (HMPREF0837_12174) | - | 1991534..1992085 (-) | 552 | WP_001111247.1 | hypothetical protein | - |
| HMPREF0837_RS10525 (HMPREF0837_12175) | - | 1992075..1992272 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| HMPREF0837_RS10530 (HMPREF0837_12176) | - | 1992276..1993070 (-) | 795 | WP_001101215.1 | hypothetical protein | - |
| HMPREF0837_RS10535 (HMPREF0837_12177) | - | 1993478..1993903 (-) | 426 | WP_000204068.1 | hypothetical protein | - |
| HMPREF0837_RS10540 (HMPREF0837_12178) | - | 1994032..1994391 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HMPREF0837_RS10545 (HMPREF0837_12179) | - | 1994437..1994643 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| HMPREF0837_RS10550 (HMPREF0837_12180) | - | 1994630..1994791 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| HMPREF0837_RS10555 (HMPREF0837_12181) | lytA | 1995150..1996106 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| HMPREF0837_RS10560 (HMPREF0837_12182) | - | 1996482..1997852 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| HMPREF0837_RS10565 (HMPREF0837_12183) | recA | 1998159..1999325 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| HMPREF0837_RS10570 (HMPREF0837_12184) | cinA | 1999380..2000636 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| HMPREF0837_RS10575 (HMPREF0837_12185) | brpA | 2000721..2001737 (-) | 1017 | WP_000239278.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| HMPREF0837_RS10580 (HMPREF0837_12186) | - | 2001745..2002263 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| HMPREF0837_RS10585 (HMPREF0837_12187) | tsaE | 2002253..2002696 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| HMPREF0837_RS10590 (HMPREF0837_12188) | comM | 2002782..2003402 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| HMPREF0837_RS10595 (HMPREF0837_12189) | - | 2003708..2004571 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| HMPREF0837_RS13220 (HMPREF0837_12190) | - | 2004762..2004932 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| HMPREF0837_RS10605 (HMPREF0837_12191) | - | 2005334..2005648 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| HMPREF0837_RS10610 (HMPREF0837_12192) | - | 2005664..2006050 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| HMPREF0837_RS10615 (HMPREF0837_12193) | - | 2006079..2007464 (+) | 1386 | WP_000813494.1 | FtsK/SpoIIIE domain-containing protein | - |
| HMPREF0837_RS12140 (HMPREF0837_12194) | - | 2007467..2007619 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| HMPREF0837_RS10620 (HMPREF0837_12195) | mobT | 2007642..2008904 (+) | 1263 | WP_001814870.1 | MobT family relaxase | - |
| HMPREF0837_RS10625 (HMPREF0837_12196) | - | 2008849..2009061 (+) | 213 | WP_029645760.1 | peptide-binding protein | - |
| HMPREF0837_RS10630 | - | 2009110..2009193 (+) | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| HMPREF0837_RS10635 (HMPREF0837_12197) | erm(B) | 2009318..2010055 (+) | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| HMPREF0837_RS10640 (HMPREF0837_12199) | - | 2010312..2011559 (-) | 1248 | WP_000019067.1 | ISL3 family transposase | - |
| HMPREF0837_RS10645 (HMPREF0837_12200) | - | 2011739..2011960 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| HMPREF0837_RS10650 (HMPREF0837_12201) | - | 2012077..2012574 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| HMPREF0837_RS10655 (HMPREF0837_12202) | - | 2012663..2013055 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| HMPREF0837_RS10660 (HMPREF0837_12203) | - | 2013039..2015486 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| HMPREF0837_RS10665 (HMPREF0837_12204) | - | 2015489..2017666 (+) | 2178 | WP_001814875.1 | CD3337/EF1877 family mobilome membrane protein | - |
| HMPREF0837_RS10670 (HMPREF0837_12205) | - | 2017663..2018664 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| HMPREF0837_RS10675 (HMPREF0837_12206) | - | 2018661..2019593 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| HMPREF0837_RS13455 | - | 2019907..2019954 (+) | 48 | Protein_2020 | hypothetical protein | - |
| HMPREF0837_RS10680 (HMPREF0837_12207) | tet(M) | 2019970..2021889 (+) | 1920 | WP_000691729.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| HMPREF0837_RS10690 (HMPREF0837_12209) | - | 2022253..2022498 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| HMPREF0837_RS10695 (HMPREF0837_12210) | - | 2022495..2022830 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| HMPREF0837_RS10700 (HMPREF0837_12211) | - | 2022843..2023211 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| HMPREF0837_RS10705 (HMPREF0837_12212) | - | 2023198..2023497 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| HMPREF0837_RS10710 (HMPREF0837_12213) | msr(D) | 2023615..2025078 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| HMPREF0837_RS10715 (HMPREF0837_12214) | mef(A) | 2025198..2026415 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| HMPREF0837_RS10720 (HMPREF0837_12215) | - | 2026801..2026971 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| HMPREF0837_RS12150 (HMPREF0837_12216) | - | 2027493..2027684 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| HMPREF0837_RS10730 (HMPREF0837_12217) | - | 2027744..2028097 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| HMPREF0837_RS10735 (HMPREF0837_12219) | - | 2028602..2029024 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| HMPREF0837_RS10740 (HMPREF0837_12220) | - | 2029021..2029251 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| HMPREF0837_RS13130 | - | 2029477..2029728 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| HMPREF0837_RS10745 (HMPREF0837_12221) | - | 2029712..2029915 (+) | 204 | WP_000814511.1 | excisionase | - |
| HMPREF0837_RS10750 (HMPREF0837_12222) | - | 2029997..2031214 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| HMPREF0837_RS10755 (HMPREF0837_12225) | - | 2032105..2034120 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| HMPREF0837_RS10760 (HMPREF0837_12226) | - | 2034122..2034754 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=37638 HMPREF0837_RS10590 WP_000839909.1 2002782..2003402(-) (comM) [Streptococcus pneumoniae TCH8431/19A]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=37638 HMPREF0837_RS10590 WP_000839909.1 2002782..2003402(-) (comM) [Streptococcus pneumoniae TCH8431/19A]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |