Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   G8B38_RS06880 Genome accession   NZ_CP049694
Coordinates   1361462..1362103 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain ABC122     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1356462..1367103
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  G8B38_RS06855 (G8B38_06895) comFA/cflA 1356548..1357873 (-) 1326 WP_011528851.1 DEAD/DEAH box helicase Machinery gene
  G8B38_RS06860 (G8B38_06900) - 1357929..1358561 (+) 633 WP_042769749.1 YigZ family protein -
  G8B38_RS06865 (G8B38_06905) cysK 1358689..1359630 (+) 942 WP_011528853.1 cysteine synthase A -
  G8B38_RS06870 (G8B38_06910) - 1359648..1360025 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  G8B38_RS06875 (G8B38_06915) - 1360025..1361425 (-) 1401 WP_021299066.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  G8B38_RS06880 (G8B38_06920) vraR 1361462..1362103 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  G8B38_RS06885 (G8B38_06925) - 1362096..1363100 (-) 1005 WP_011528855.1 sensor histidine kinase -
  G8B38_RS06890 (G8B38_06930) liaF 1363097..1363789 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  G8B38_RS06895 (G8B38_06935) pknB 1363912..1365810 (-) 1899 WP_011018054.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  G8B38_RS06900 (G8B38_06940) - 1365807..1366547 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=374900 G8B38_RS06880 WP_002983671.1 1361462..1362103(-) (vraR) [Streptococcus pyogenes strain ABC122]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=374900 G8B38_RS06880 WP_002983671.1 1361462..1362103(-) (vraR) [Streptococcus pyogenes strain ABC122]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment