Detailed information NTG0373541

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FO459_RS01395
• Genome accession: NZ_CP041727
• Coordinates: 270716..271759 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain SL122
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 265716..276759

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FO459_RS01370 (FO459_01370)	-	266006..267367 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
FO459_RS01375 (FO459_01375)	-	267501..268481 (-)	981	WP_002477959.1	FUSC family protein	-
FO459_RS01380 (FO459_01380)	map	268726..269481 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
FO459_RS01385 (FO459_01385)	-	269607..269993 (+)	387	WP_002477960.1	hypothetical protein	-
FO459_RS01390 (FO459_01390)	liaF	270018..270719 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
FO459_RS01395 (FO459_01395)	vraS	270716..271759 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
FO459_RS01400 (FO459_01400)	vraR	271749..272378 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
FO459_RS01405 (FO459_01405)	-	272551..273780 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
FO459_RS01410 (FO459_01410)	-	273983..274267 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
FO459_RS01415 (FO459_01415)	-	274274..274738 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
FO459_RS01420 (FO459_01420)	-	274902..275087 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
FO459_RS01425 (FO459_01425)	-	275100..276338 (+)	1239	WP_002477963.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=373541 FO459_RS01395 WP_002461334.1 270716..271759(+) (vraS) [Staphylococcus lugdunensis strain SL122]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=373541 FO459_RS01395 WP_002461334.1 270716..271759(+) (vraS) [Staphylococcus lugdunensis strain SL122]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCGCTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911