Detailed information NTG0373411

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FO455_RS01175
• Genome accession: NZ_CP041723
• Coordinates: 233268..234311 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain SL29
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 228268..239311

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FO455_RS01150 (FO455_01150)	-	228558..229919 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
FO455_RS01155 (FO455_01155)	-	230053..231033 (-)	981	WP_002477959.1	FUSC family protein	-
FO455_RS01160 (FO455_01160)	map	231278..232033 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
FO455_RS01165 (FO455_01165)	-	232159..232545 (+)	387	WP_002477960.1	hypothetical protein	-
FO455_RS01170 (FO455_01170)	liaF	232570..233271 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
FO455_RS01175 (FO455_01175)	vraS	233268..234311 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
FO455_RS01180 (FO455_01180)	vraR	234301..234930 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
FO455_RS01185 (FO455_01185)	-	235103..236332 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
FO455_RS01190 (FO455_01190)	-	236535..236819 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
FO455_RS01195 (FO455_01195)	-	236826..237290 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
FO455_RS01200 (FO455_01200)	-	237454..237639 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
FO455_RS01205 (FO455_01205)	-	237652..238890 (+)	1239	WP_002477963.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=373411 FO455_RS01175 WP_002461334.1 233268..234311(+) (vraS) [Staphylococcus lugdunensis strain SL29]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=373411 FO455_RS01175 WP_002461334.1 233268..234311(+) (vraS) [Staphylococcus lugdunensis strain SL29]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCGCTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911