Detailed information NTG0369104

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FIV54_RS04420
• Genome accession: NZ_CP041037
• Coordinates: 866671..867714 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NP66
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 861671..872714

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FIV54_RS04390 (FIV54_04395)	-	862156..862266 (+)	111	WP_001790257.1	hypothetical protein	-
FIV54_RS04395 (FIV54_04400)	-	862295..862708 (+)	414	WP_001566709.1	hypothetical protein	-
FIV54_RS04400 (FIV54_04405)	-	863139..864125 (-)	987	WP_145326043.1	aromatic acid exporter family protein	-
FIV54_RS04405 (FIV54_04410)	map	864597..865355 (+)	759	WP_000636138.1	type I methionyl aminopeptidase	-
FIV54_RS04410 (FIV54_04415)	-	865572..865958 (+)	387	WP_001110179.1	hypothetical protein	-
FIV54_RS04415 (FIV54_04420)	liaF	865973..866674 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FIV54_RS04420 (FIV54_04425)	vraS	866671..867714 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FIV54_RS04425 (FIV54_04430)	vraR	867704..868333 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
FIV54_RS04430 (FIV54_04435)	-	868445..869662 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
FIV54_RS04435 (FIV54_04440)	-	869940..870215 (-)	276	WP_000428171.1	hypothetical protein	-
FIV54_RS04440 (FIV54_04445)	-	870222..870686 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FIV54_RS04445 (FIV54_04450)	-	870833..871033 (+)	201	WP_000180460.1	DUF1128 family protein	-
FIV54_RS04450 (FIV54_04455)	-	871036..872292 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=369104 FIV54_RS04420 WP_001017131.1 866671..867714(+) (vraS) [Staphylococcus aureus strain NP66]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=369104 FIV54_RS04420 WP_001017131.1 866671..867714(+) (vraS) [Staphylococcus aureus strain NP66]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1