Detailed information NTG0367211

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: FDP16_RS02840
• Genome accession: NZ_CP040798
• Coordinates: 561676..562365 (+)
• Length: 229 a.a.
• NCBI ID: WP_176798491.1
• Uniprot ID: A0A7H8UYU4
• Organism: Streptococcus sanguinis strain CGMH058
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 556676..567365

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FDP16_RS02825 (FDP16_02930)	-	556773..558008 (+)	1236	WP_061595410.1	DNA cytosine methyltransferase	-
FDP16_RS02830 (FDP16_02935)	-	558063..559847 (-)	1785	WP_176798489.1	ATP-binding protein	-
FDP16_RS11755 (FDP16_02940)	-	559961..560080 (-)	120	Protein_524	8-oxo-dGTP diphosphatase MutT	-
FDP16_RS02835 (FDP16_02945)	gndA	560242..561666 (+)	1425	WP_176798490.1	NADP-dependent phosphogluconate dehydrogenase	-
FDP16_RS02840 (FDP16_02950)	covR	561676..562365 (+)	690	WP_176798491.1	response regulator transcription factor	Regulator
FDP16_RS02845 (FDP16_02955)	-	562651..564843 (+)	2193	WP_176798492.1	PTS transporter subunit IIBC	-
FDP16_RS02850 (FDP16_02960)	-	564861..565676 (+)	816	WP_176798493.1	endonuclease/exonuclease/phosphatase family protein	-
FDP16_RS02855 (FDP16_02965)	nrdR	565847..566320 (+)	474	WP_002894570.1	transcriptional regulator NrdR	-

Sequence

Protein

• Length: 229 a.a.
• Molecular weight: 26355.36 Da
• Isoelectric Point: 5.2030

>NTDB_id=367211 FDP16_RS02840 WP_176798491.1 561676..562365(+) (covR) [Streptococcus sanguinis strain CGMH058]
MAKRILLVENEKNLARFVSLELQKESFLVDSAETGQEGLALAKDVDYDLLLLNYDLQDMTASDFAKQLSLIKPASVIIVL
ASREEIAEQQEVIQHFAVSYVVKPFIISDLVERVSIIFRGRDFIDQHCSLLKIPTSYRNLRVDIKNHTVYRGEEVIALTR
REYDLLVTLMGSNKVMSREQLLERVWKYESATETNVVDVYIRYLRSKIDVEGQPSYIKTVRGVGYAMQE

Nucleotide

• Length: 690 bp

>NTDB_id=367211 FDP16_RS02840 WP_176798491.1 561676..562365(+) (covR) [Streptococcus sanguinis strain CGMH058]
ATGGCAAAGCGAATTTTACTAGTAGAAAATGAAAAAAATCTTGCACGGTTTGTGAGTTTGGAACTGCAAAAGGAAAGCTT
TCTTGTAGATTCAGCTGAGACAGGTCAAGAGGGACTGGCTCTGGCTAAAGATGTGGACTATGACTTGCTCTTGCTCAACT
ATGATCTTCAAGATATGACTGCCAGCGATTTTGCTAAGCAGCTGAGCTTGATTAAGCCAGCGTCCGTCATTATCGTTCTG
GCTAGTCGCGAAGAAATTGCAGAGCAGCAGGAGGTAATCCAGCATTTTGCTGTTTCCTACGTGGTCAAGCCTTTCATTAT
CAGTGATTTAGTGGAGCGCGTCTCTATCATTTTCCGCGGGCGCGACTTTATCGACCAGCACTGCAGCCTCTTGAAAATTC
CGACCTCTTACCGCAATCTGCGAGTGGATATTAAAAATCACACGGTTTACCGCGGTGAGGAAGTCATTGCGCTGACGCGG
AGGGAGTACGATCTTCTGGTGACCCTGATGGGCAGCAATAAGGTCATGAGCCGTGAGCAATTGCTGGAGCGTGTCTGGAA
GTACGAGAGTGCAACCGAGACCAACGTTGTAGATGTTTATATTCGTTATCTGCGCAGTAAAATTGATGTGGAAGGGCAGC
CAAGCTATATCAAAACCGTTCGCGGTGTTGGTTATGCCATGCAAGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-114)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-227)

3D structure

• AlphaFold DB: A0A7H8UYU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Streptococcus salivarius strain HSISS4	49.13	100	0.493
covR	Lactococcus lactis subsp. lactis strain DGCC12653	48.035	100	0.48