Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   M594_RS09350 Genome accession   NZ_CP047883
Coordinates   1942493..1944442 (-) Length   649 a.a.
NCBI ID   WP_173876645.1    Uniprot ID   -
Organism   Streptococcus mitis strain S022-V3-A4     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1937493..1949442
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS09320 (M594_09360) - 1937782..1938726 (+) 945 WP_000815623.1 magnesium transporter CorA family protein -
  M594_RS09325 (M594_09365) - 1938738..1939415 (+) 678 WP_000078011.1 DUF1129 domain-containing protein -
  M594_RS09330 (M594_09370) - 1939557..1940588 (+) 1032 WP_173876644.1 S66 family peptidase -
  M594_RS09335 (M594_09375) - 1940640..1941314 (-) 675 WP_153210263.1 CPBP family intramembrane glutamic endopeptidase -
  M594_RS09340 (M594_09380) - 1941311..1941874 (-) 564 WP_153210262.1 DNA-3-methyladenine glycosylase I -
  M594_RS09345 (M594_09385) ruvA 1941884..1942477 (-) 594 WP_153210261.1 Holliday junction branch migration protein RuvA Machinery gene
  M594_RS09350 (M594_09390) hexB 1942493..1944442 (-) 1950 WP_173876645.1 DNA mismatch repair endonuclease MutL Machinery gene
  M594_RS09355 (M594_09400) - 1944650..1945090 (+) 441 WP_173876646.1 LytTR family DNA-binding domain-containing protein -
  M594_RS09360 (M594_09405) - 1945087..1945545 (+) 459 WP_173876647.1 DUF3021 domain-containing protein -
  M594_RS09365 (M594_09410) hexA 1945587..1948121 (-) 2535 WP_173876648.1 DNA mismatch repair protein MutS Machinery gene
  M594_RS09370 (M594_09415) argR 1948172..1948618 (-) 447 WP_001231476.1 arginine repressor -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73520.92 Da        Isoelectric Point: 5.1230

>NTDB_id=366351 M594_RS09350 WP_173876645.1 1942493..1944442(-) (hexB) [Streptococcus mitis strain S022-V3-A4]
MSHIIELPEVLANQIAAGEVIERPASVVKELVENAIDADSSQIIIEIEEAGLKKIQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSILTLLTAVEEASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTQTAGTGQLRQAIAGIYGLASAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMALVSE
AIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPTRPSQAEVADYQVELTEEGQDLTLFAKETLD
RLTKPAKLHFAERKPANYDQLDHPELDLVSLDKAYDKLEREESSSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMALLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=366351 M594_RS09350 WP_173876645.1 1942493..1944442(-) (hexB) [Streptococcus mitis strain S022-V3-A4]
ATGTCTCATATTATTGAATTGCCAGAGGTGCTGGCAAACCAGATTGCAGCTGGGGAGGTCATTGAACGTCCTGCTAGCGT
TGTTAAGGAGCTGGTAGAAAATGCCATTGACGCGGATTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AAATTCAAATCACAGATAATGGTCATGGAATTGCCCACGATGAGGTGGAATTGGCCCTGCGTCGTCATGCGACCAGTAAG
ATAAAAAATCAAGCAGACCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCCTGCCCTCTATCGCGTCTGTCAG
CATTTTAACTCTTTTGACAGCAGTTGAGGAAGCAAGTCATGGGACCAAGCTAGTCGCGCGTGGGGGTGAAGTTGAGGAAG
TCATCCCGGCGACTAGTCCTGTGGGGACCAAAGTTTGTGTGGAGGACCTCTTTTTCAACACGCCTGCCCGCCTCAAGTAT
ATGAAGAGCCAGCAAGCAGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTAGCCCATCCTGAAATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCAGACAGCTGGGACTGGTCAACTGCGCCAAGCTATTGCAGGGATTTACG
GTTTAGCCAGCGCCAAGAAGATGATTGAAATTGAGAATTCTGACCTTGATTTCGAAATTTCAGGTTTTGTGTCTCTGCCT
GAGTTGACTCGGGCTAATCGCAACTATATCAGCCTCTTCATCAATGGCCGTTATATCAAGAACTTTCTGCTCAATCGTGC
AATTCTAGACGGCTATGGCAGTAAGCTCATGGTGGGACGCTTTCCGTTGGCTGTCATTCATATCCATATTGACCCTTATC
TAGCGGATGTCAATGTTCATCCAACCAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAATTGATGGCCTTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAGCAAACTTTGATACCTGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGTAATCG
TGAGAAGGTGGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACTGAGCCGACAAGACCTAGTC
AAGCTGAGGTGGCTGATTATCAGGTAGAATTGACTGAGGAAGGGCAGGATTTAACCCTATTTGCCAAAGAAACCTTGGAC
CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGATCATCCAGAGTTAGA
CCTTGTGAGTCTTGATAAGGCTTATGACAAGCTGGAGCGAGAAGAATCTTCCAGCTTCCCAGAGTTGGAATTTTTCGGGC
AAATGCATGGAACCTATCTCTTTGCCCAAGGGCGAGATGGACTTTACATCATAGACCAGCATGCGGCACAGGAACGGGTC
AAGTACGAGGAGTATCGTGAAAGCATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTAGTGCCCTATATTTTTGAATT
TCCCGCAGATGATGCCCTTCGTCTTAAGGAAAGAATGGCACTTTTAGAGGAAGTTGGAGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATCTTACGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAGTCAGGCATCTATGAAATGTGCGAC
ATGCTCCTTTTAACCAAGGAAGTTTCTATCAAGAAATATCGAGCAGAGCTAGCTATCATGATGTCCTGCAAACGGTCTAT
CAAGGCCAACCATCGTATCGATGACCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCTTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTCACTAAGTCGGATATGGAAAAGATGTTTCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-99)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

97.381

100

0.974

Multiple sequence alignment