Detailed information NTG0365834

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: FF957_RS10360
• Genome accession: NZ_CP040619
• Coordinates: 2024873..2025916 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain J01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2019873..2030916

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FF957_RS10330 (FF957_10330)	-	2020291..2021547 (-)	1257	WP_001795438.1	aminopeptidase	-
FF957_RS10335 (FF957_10335)	-	2021550..2021750 (-)	201	WP_000180461.1	DUF1128 family protein	-
FF957_RS10340 (FF957_10340)	-	2021897..2022361 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
FF957_RS10345 (FF957_10345)	-	2022368..2022643 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
FF957_RS10350 (FF957_10350)	-	2022921..2024138 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
FF957_RS10355 (FF957_10355)	vraR	2024254..2024883 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
FF957_RS10360 (FF957_10360)	vraS	2024873..2025916 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
FF957_RS10365 (FF957_10365)	liaF	2025913..2026614 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
FF957_RS10370 (FF957_10370)	-	2026629..2027015 (-)	387	WP_001110179.1	hypothetical protein	-
FF957_RS10375 (FF957_10375)	map	2027232..2027990 (-)	759	WP_138642981.1	type I methionyl aminopeptidase	-
FF957_RS10380 (FF957_10380)	-	2028577..2029563 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
FF957_RS10385 (FF957_10385)	-	2029994..2030407 (-)	414	WP_001549145.1	hypothetical protein	-
FF957_RS10390 (FF957_10390)	-	2030436..2030546 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=365834 FF957_RS10360 WP_001017131.1 2024873..2025916(-) (vraS) [Staphylococcus aureus strain J01]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=365834 FF957_RS10360 WP_001017131.1 2024873..2025916(-) (vraS) [Staphylococcus aureus strain J01]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1