Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SMI_RS08880 Genome accession   NC_013853
Coordinates   1803357..1804046 (-) Length   229 a.a.
NCBI ID   WP_000518031.1    Uniprot ID   D3HAU0
Organism   Streptococcus mitis B6     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1798357..1809046
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS08855 (smi_1744) fni 1798393..1799403 (-) 1011 WP_000210637.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  SMI_RS08860 (smi_1745) - 1799387..1800394 (-) 1008 WP_000226748.1 phosphomevalonate kinase -
  SMI_RS08865 (smi_1746) mvaD 1800381..1801334 (-) 954 WP_000373473.1 diphosphomevalonate decarboxylase -
  SMI_RS08870 (smi_1747) mvk 1801316..1802194 (-) 879 WP_000163300.1 mevalonate kinase -
  SMI_RS08875 (smi_1748) - 1802317..1803258 (-) 942 WP_000691497.1 N-acetylmuramoyl-L-alanine amidase family protein -
  SMI_RS08880 (smi_1749) covR 1803357..1804046 (-) 690 WP_000518031.1 response regulator transcription factor Regulator
  SMI_RS08885 (smi_1750) gndA 1804058..1805482 (-) 1425 WP_000158778.1 NADP-dependent phosphogluconate dehydrogenase -
  SMI_RS08890 (smi_1751) mapZ 1805558..1806952 (-) 1395 WP_000039110.1 cell division site-positioning protein MapZ -
  SMI_RS08895 (smi_1752) - 1806965..1808122 (-) 1158 WP_000711367.1 THUMP domain-containing class I SAM-dependent RNA methyltransferase -
  SMI_RS08905 (smi_1754) gpsB 1808608..1808949 (-) 342 WP_000094897.1 cell division regulator GpsB -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26741.90 Da        Isoelectric Point: 8.6485

>NTDB_id=36332 SMI_RS08880 WP_000518031.1 1803357..1804046(-) (covR) [Streptococcus mitis B6]
MGKRILLLEKERNLAHFLSLELQKEQYRVDQVEEGQKALSMALQTDYDLILLNARLGDMTAQDFADKLSRTKPASVIMVL
DHREELQGQIETIQRFAVSYIYKPVIIENLVARISAIFRGRDFIDQHCSQMKVPTSYRNLRMDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=36332 SMI_RS08880 WP_000518031.1 1803357..1804046(-) (covR) [Streptococcus mitis B6]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCACTTTTTAAGTTTGGAACTCCAAAAAGAGCAATA
CCGAGTTGATCAGGTTGAGGAGGGGCAAAAAGCCCTCTCCATGGCTCTTCAGACAGACTATGACTTGATTTTATTGAATG
CTCGTCTGGGGGATATGACAGCCCAGGATTTTGCAGACAAGCTGAGTCGGACTAAGCCAGCCTCAGTCATCATGGTTTTG
GACCATCGTGAAGAATTGCAAGGTCAGATTGAGACAATCCAACGCTTTGCCGTTTCTTACATCTATAAGCCGGTTATTAT
TGAGAATCTGGTAGCTCGTATTTCAGCGATTTTCCGAGGTCGGGACTTTATCGACCAACACTGTAGTCAGATGAAGGTTC
CAACGTCTTACCGCAATCTGCGTATGGATGTAGAACATCATACCGTTTATCGTGGCGAGGAGATGATTGCTCTGACGCGT
CGTGAGTATGACCTTTTGGCCACTCTTATGGGAAGCAAGAAAGTTCTGACTCGTGAGCAGTTGTTGGAAAGTGTCTGGAA
GTATGAAAGTGCGACCGAAACAAATATCGTGGATGTCTATATCCGTTATCTACGTAGCAAGCTTGATGTAAAAGGTCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGTTACACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3HAU0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.696

100

0.489
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.491

99.563

0.463

Multiple sequence alignment