Detailed information NTG0036295

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SMI_RS01645
• Genome accession: NC_013853
• Coordinates: 310717..311754 (+)
• Length: 345 a.a.
• NCBI ID: WP_012972442.1
• Uniprot ID: D3H6U6
• Organism: Streptococcus mitis B6
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 305717..316754

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMI_RS01610 (smi_0310)	yidC	305752..306678 (-)	927	WP_000835951.1	membrane protein insertase YidC	-
SMI_RS01615	-	306756..307036 (-)	281	Protein_292	acylphosphatase	-
SMI_RS01620 (smi_0311)	-	307070..307810 (+)	741	WP_000152675.1	TrmH family RNA methyltransferase	-
SMI_RS01625 (smi_0312)	-	307865..308548 (+)	684	WP_001109987.1	Bax inhibitor-1/YccA family protein	-
SMI_RS01630 (smi_0313)	asnA	308659..309651 (+)	993	WP_000747996.1	aspartate--ammonia ligase	-
SMI_RS01635 (smi_0314)	rsmD	309716..310255 (+)	540	WP_000706956.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SMI_RS01640 (smi_0315)	coaD	310245..310733 (+)	489	WP_001280758.1	pantetheine-phosphate adenylyltransferase	-
SMI_RS01645 (smi_0316)	sepM	310717..311754 (+)	1038	WP_012972442.1	SepM family pheromone-processing serine protease	Regulator
SMI_RS01650	-	311812..312042 (+)	231	WP_000250385.1	DUF1146 family protein	-
SMI_RS01655 (smi_0317)	murA	312065..313348 (+)	1284	WP_000411895.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SMI_RS01660 (smi_0318)	-	313341..313529 (+)	189	WP_164925506.1	DNA-directed RNA polymerase subunit beta	-
SMI_RS01665 (smi_0319)	endA	313568..314398 (+)	831	WP_001036774.1	DNA-entry nuclease EndA	Machinery gene
SMI_RS01670 (smi_0320)	-	314660..315991 (+)	1332	WP_000390035.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.54 Da
• Isoelectric Point: 4.8665

>NTDB_id=36295 SMI_RS01645 WP_012972442.1 310717..311754(+) (sepM) [Streptococcus mitis B6]
MKKKTRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGTSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYLGVYVLTVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVNSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVTSDVPIRFSTAGIGGPSAGLMFSL
AIYTQIADPGLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASAREGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=36295 SMI_RS01645 WP_012972442.1 310717..311754(+) (sepM) [Streptococcus mitis B6]
ATGAAAAAAAAGACTAGATGGCCCTTATATGTCATTGCGGCCTTAATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
CTACTATATAGAAGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GGGCCTATCAATTCGTTACGGTTGGTGTCCAGCATGCTACTTTAGCCCATATGATTTATGCGTGGTTGACGCCTTTTACA
GATATTCGCAGTGCTCAGGAGACTACAGGCGGAACTTCCGATGTTGAATTTATGCGGATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAATATCAAGGACTAAAAACAGCTGGTAAGGATATTGAACTTAAATACCTTGGGGTTTATGTTT
TGACTGTGACGGATAATTCGACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACCGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGATTTGATTGATTACGTCAATTCTCAAAAACTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGTAAGATTATCACCTTGGAAAATGGCAAAAATGGGATTGGAATCGGCTTGATTGACCGTA
CGGAAGTGACCAGTGATGTCCCAATTCGCTTTTCAACAGCTGGTATCGGCGGACCAAGTGCTGGCCTCATGTTTAGTCTG
GCTATCTATACTCAAATAGCTGACCCTGGCCTTCGTAATGGCCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
GAATGTGGGGGACATTGGAGGTATTGATAAGAAAGTTGTAGCTTCGGCTAGAGAAGGTGCTGCGATTTTCTTTGCCCCAG
ATAACCCTGTTAGCGAAGAAGAACAAAAAGCGCATCCTGATGCGAAAAACAACTACCAGACAGCCTTAGAAGCAGCTAAA
ACAATCAAGACAGATATGAAAATCGTTCCAGTTAAAACCCTACAAGATGCAATTGATTACTTGAAAAACAATCCCTAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

• PDZ domain (PDZ_2) (129-193)

3D structure

• AlphaFold DB: D3H6U6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591