Detailed information NTG0357876

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: GQY29_RS02660
• Genome accession: NZ_CP047191
• Coordinates: 494205..496763 (-)
• Length: 852 a.a.
• NCBI ID: WP_023909315.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain EU01
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 489205..501763

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GQY29_RS02630 (GQY29_02630)	ruvA	489711..490301 (-)	591	WP_011680603.1	Holliday junction branch migration protein RuvA	Machinery gene
GQY29_RS02635 (GQY29_02635)	-	490453..490674 (-)	222	WP_011680602.1	hypothetical protein	-
GQY29_RS02640 (GQY29_02640)	hexB	490804..492747 (-)	1944	WP_011680601.1	DNA mismatch repair endonuclease MutL	Machinery gene
GQY29_RS02645 (GQY29_02645)	-	492799..493104 (-)	306	WP_014621013.1	hypothetical protein	-
GQY29_RS02650 (GQY29_02650)	-	493328..493719 (+)	392	Protein_475	LytTR family DNA-binding domain-containing protein	-
GQY29_RS11090 (GQY29_02655)	-	493716..494171 (+)	456	Protein_476	DUF3021 domain-containing protein	-
GQY29_RS02660 (GQY29_02660)	hexA	494205..496763 (-)	2559	WP_023909315.1	DNA mismatch repair protein MutS	Machinery gene
GQY29_RS02665 (GQY29_02665)	-	496756..497115 (-)	360	WP_011225277.1	YlbF family regulator	-
GQY29_RS02670 (GQY29_02670)	argR	497115..497543 (-)	429	WP_024704313.1	arginine repressor	-
GQY29_RS02675 (GQY29_02675)	argS	497698..499389 (+)	1692	WP_014607827.1	arginine--tRNA ligase	-
GQY29_RS02680 (GQY29_02680)	purB	500253..501551 (-)	1299	WP_002948159.1	adenylosuccinate lyase	-

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95525.77 Da
• Isoelectric Point: 4.7204

>NTDB_id=357876 GQY29_RS02660 WP_023909315.1 494205..496763(-) (hexA) [Streptococcus thermophilus strain EU01]
MAKEKISPGMQQYLDIKKNYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKETEGYDDVHLIGNSLTDLESSVASKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDKTKTAMGMRLLRTWIDRPLVNQASIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGHTLAQVPIIKAILESFNDDALSGLLQELDALPELESLIRSAIDP
DAPATITEGGIIRDGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAETNHYVRPVFN
DEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPVFDA
IYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLIHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPTDLLNRADTILTQLEGETVVIQPQEKVSSQ
EKPAIETHVNEQISLFDDFTENPVLQELRDLDIYNMTPMQVMMAVEDLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=357876 GQY29_RS02660 WP_023909315.1 494205..496763(-) (hexA) [Streptococcus thermophilus strain EU01]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGAAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTGTTAAGGCTGCCCAGATTTTGGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTAAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCCATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACAGAGTTGGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCACGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTACTTCTCTCCAAGGAAACAGAAGGTTACGATGATGTTCACTTGATTGGTAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCAAGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGCAAGAAACACGGTTCTCTTTTCTGGCTCTTGGATAAAACCAAGACAGCCATGGGAATGCGTCTCTTGCGAACTT
GGATTGATCGTCCTTTAGTGAATCAAGCCAGCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAGCGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTAATTCAGCTAGGTCATACCTTAGCTCAGGTTCCGATCATTAAGGCAATCTTGGAGTCCTTTAATG
ACGATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTCGTTCGGCTATTGATCCT
GATGCTCCAGCAACAATTACAGAAGGTGGTATTATTCGTGATGGTTTTGATGAGACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCAAAAGAACGCGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTACTTCCATGTGACCAACTCTAACCTTAGTTTGGTTCCTGACCATTTCTTCCGTAAGGCG
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCACGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAGGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGCCATTGCAACAGTCGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGACAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCGCTATTGATCGGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACGTACCAGCAGATAGTGTTGATTTACCTGTTTTTGACGCC
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGATGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTTGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTGTCAAACAGTTTGATACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCCGATAAATCGTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAACAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTCAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCTCTCTCTTTGATGACTTTACTGAAAATCCGGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGAAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain I (MutS_I) (8-118)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.944	100	0.739
mutS	Pseudomonas stutzeri strain ATCC 17587	35.788	100	0.365