Detailed information    

insolico Bioinformatically predicted

Overview

Name   sigH   Type   Regulator
Locus tag   E1950_RS02350 Genome accession   NZ_CP039162
Coordinates   476239..476808 (+) Length   189 a.a.
NCBI ID   WP_000872882.1    Uniprot ID   A0A7U7EXA1
Organism   Staphylococcus aureus strain Lr12     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 471239..481808
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E1950_RS02325 (E1950_02375) cysE 472452..473099 (+) 648 WP_001805237.1 serine O-acetyltransferase -
  E1950_RS02330 (E1950_02380) cysS 473083..474483 (+) 1401 WP_000631969.1 cysteine--tRNA ligase -
  E1950_RS02335 (E1950_02385) - 474476..474880 (+) 405 WP_000370182.1 Mini-ribonuclease 3 -
  E1950_RS02340 (E1950_02390) rlmB 474888..475634 (+) 747 WP_000390332.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
  E1950_RS02345 (E1950_02395) - 475634..476158 (+) 525 WP_000664737.1 NYN domain-containing protein -
  E1950_RS02350 (E1950_02400) sigH 476239..476808 (+) 570 WP_000872882.1 sigma-70 family RNA polymerase sigma factor Regulator
  E1950_RS02355 (E1950_02405) rpmG 476923..477066 (+) 144 WP_001788193.1 50S ribosomal protein L33 -
  E1950_RS02360 (E1950_02410) secE 477122..477304 (+) 183 WP_001074473.1 preprotein translocase subunit SecE -
  E1950_RS02365 (E1950_02415) nusG 477317..477865 (+) 549 WP_001288302.1 transcription termination/antitermination protein NusG -
  E1950_RS02370 (E1950_02420) rplK 478046..478468 (+) 423 WP_001085792.1 50S ribosomal protein L11 -
  E1950_RS02375 (E1950_02425) rplA 478676..479368 (+) 693 WP_001074619.1 50S ribosomal protein L1 -
  E1950_RS02385 (E1950_02435) rplJ 479640..480140 (+) 501 WP_001273085.1 50S ribosomal protein L10 -
  E1950_RS02390 (E1950_02440) rplL 480183..480551 (+) 369 WP_001273586.1 50S ribosomal protein L7/L12 -
  E1950_RS02395 (E1950_02445) - 480726..481334 (+) 609 WP_000020304.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 189 a.a.        Molecular weight: 23044.91 Da        Isoelectric Point: 9.4170

>NTDB_id=357322 E1950_RS02350 WP_000872882.1 476239..476808(+) (sigH) [Staphylococcus aureus strain Lr12]
MKYDLTTQDSTIKRNNSINDKDFEKLVMDLQPLIIRRIKTFGFNHYDLEDLYQEILIRMYRSVQTFDFSGEQPFTNYVQC
LITSVKYDYLRKYLATNKRMDNLINEYRVTYPCAIKRFDVENNYLNKLAIKELICQFKYLSAFEKDVMYLMCEQYKPREI
AQLMHVKEKVIYNAIQRCKNKIKRYFKMI

Nucleotide


Download         Length: 570 bp        

>NTDB_id=357322 E1950_RS02350 WP_000872882.1 476239..476808(+) (sigH) [Staphylococcus aureus strain Lr12]
TTGAAATATGATTTGACAACTCAAGACAGTACAATCAAACGTAACAATTCAATAAATGATAAAGACTTCGAAAAGTTAGT
AATGGATCTACAACCATTAATTATTCGACGCATCAAAACATTTGGATTTAATCATTATGATTTAGAAGACTTATATCAAG
AAATACTTATACGGATGTATAGGTCGGTCCAAACATTTGATTTTAGTGGAGAGCAGCCTTTCACAAATTATGTTCAATGT
TTAATTACGTCTGTAAAGTATGATTATTTGAGAAAATATTTAGCTACAAATAAAAGAATGGATAATTTGATTAATGAATA
TAGAGTTACGTATCCATGTGCAATAAAGCGTTTTGATGTTGAAAACAATTATTTGAATAAATTAGCAATTAAAGAGTTGA
TTTGTCAGTTTAAGTATTTGAGTGCATTTGAAAAAGATGTCATGTATTTAATGTGTGAACAATATAAGCCGAGAGAAATT
GCTCAATTGATGCATGTAAAAGAGAAAGTGATTTATAATGCCATACAACGATGTAAAAATAAAATAAAACGTTATTTCAA
AATGATTTGA

Domains

Predicted by InterproScan.

Sigma-70 region 2 (Sigma70_r2)

(26-92)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7EXA1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sigH Staphylococcus aureus N315

100

100

1
  sigH Staphylococcus aureus MW2

97.884

100

0.979

Multiple sequence alignment