Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   GN312_RS25735 Genome accession   NZ_CP046527
Coordinates   5120870..5121526 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain RM19259     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 5115870..5126526
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GN312_RS25705 (GN312_25705) yecA 5117122..5117787 (-) 666 WP_000847882.1 UPF0149 family protein YecA -
  GN312_RS25725 (GN312_25725) pgsA 5118436..5118984 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  GN312_RS25730 (GN312_25730) uvrC 5119041..5120873 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  GN312_RS25735 (GN312_25735) letA 5120870..5121526 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  GN312_RS28835 - 5121668..5121784 (+) 117 WP_001302039.1 hypothetical protein -
  GN312_RS25740 (GN312_25740) yecU 5121822..5121998 (+) 177 WP_001302050.1 protein YecU -
  GN312_RS25745 (GN312_25745) yecF 5121985..5122209 (+) 225 WP_000106478.1 DUF2594 family protein YecF -
  GN312_RS25750 (GN312_25750) sdiA 5122277..5122999 (-) 723 WP_001154288.1 transcriptional regulator SdiA -
  GN312_RS25755 (GN312_25755) tcyN 5123229..5123981 (-) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  GN312_RS25760 (GN312_25760) tcyL 5123978..5124646 (-) 669 WP_001158226.1 cystine ABC transporter permease -
  GN312_RS25765 (GN312_25765) dcyD 5124661..5125647 (-) 987 WP_001128225.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=353052 GN312_RS25735 WP_000611328.1 5120870..5121526(-) (letA) [Escherichia coli strain RM19259]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=353052 GN312_RS25735 WP_000611328.1 5120870..5121526(-) (letA) [Escherichia coli strain RM19259]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482

Multiple sequence alignment