Detailed information NTG0352939

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO55_RS10250
• Genome accession: NZ_CP038268
• Coordinates: 1984127..1985170 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain O55 isolate B118
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1979127..1990170

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO55_RS10220 (SaO55_1895)	-	1979546..1980802 (-)	1257	WP_001793428.1	aminopeptidase	-
SaO55_RS10225 (SaO55_1896)	-	1980805..1981007 (-)	203	Protein_1902	DUF1128 family protein	-
SaO55_RS10230 (SaO55_1897)	-	1981154..1981618 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SaO55_RS10235 (SaO55_1898)	-	1981625..1981900 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO55_RS10240 (SaO55_1899)	-	1982178..1983395 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
SaO55_RS10245 (SaO55_1900)	vraR	1983508..1984137 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SaO55_RS10250 (SaO55_1901)	vraS	1984127..1985170 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO55_RS10255 (SaO55_1902)	liaF	1985167..1985868 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SaO55_RS10260 (SaO55_1903)	-	1985883..1986269 (-)	387	WP_001110175.1	hypothetical protein	-
SaO55_RS10265 (SaO55_1904)	map	1986486..1987244 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO55_RS10280 (SaO55_1905)	-	1987828..1988814 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SaO55_RS10285 (SaO55_1906)	-	1989003..1989416 (-)	414	WP_078064660.1	hypothetical protein	-
SaO55_RS10290	-	1989445..1989557 (-)	113	Protein_1913	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=352939 SaO55_RS10250 WP_001017131.1 1984127..1985170(-) (vraS) [Staphylococcus aureus strain O55 isolate B118]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=352939 SaO55_RS10250 WP_001017131.1 1984127..1985170(-) (vraS) [Staphylococcus aureus strain O55 isolate B118]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1