Detailed information NTG0352601

Bioinformatically predicted

Overview

• Name: ccpA
• Type: Regulator
• Locus tag: ES276_RS01615
• Genome accession: NZ_CP038252
• Coordinates: 297995..299005 (+)
• Length: 336 a.a.
• NCBI ID: WP_000990607.1
• Uniprot ID: A0A0B7LZL8
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: regulate comCDE transcription and transformation (predicted from homology) Competence regulation

Genomic Context

Location: 292995..304005

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS01585	-	293866..294072 (+)	207	Protein_303	hypothetical protein	-
ES276_RS01590 (ES276_01685)	-	294069..294263 (+)	195	WP_000820189.1	hypothetical protein	-
ES276_RS01595 (ES276_01690)	-	294250..295134 (+)	885	WP_001055978.1	ABC transporter ATP-binding protein	-
ES276_RS01600 (ES276_01695)	-	295136..295873 (+)	738	WP_000832915.1	ABC transporter permease	-
ES276_RS01605 (ES276_01700)	-	295873..296970 (+)	1098	WP_000893503.1	sensor histidine kinase	-
ES276_RS01610 (ES276_01705)	-	296971..297570 (+)	600	WP_000866703.1	response regulator transcription factor	-
ES276_RS01615 (ES276_01710)	ccpA	297995..299005 (+)	1011	WP_000990607.1	catabolite control protein A	Regulator
ES276_RS01620 (ES276_01715)	-	299069..299497 (+)	429	WP_001092023.1	hypothetical protein	-
ES276_RS01625 (ES276_01720)	-	299526..300488 (-)	963	WP_001124777.1	asparaginase	-
ES276_RS01630 (ES276_01725)	-	300554..301942 (+)	1389	WP_000453137.1	Cof-type HAD-IIB family hydrolase	-
ES276_RS01635 (ES276_01730)	-	301977..302429 (-)	453	WP_000079148.1	universal stress protein	-
ES276_RS01640 (ES276_01735)	-	302591..302885 (+)	295	Protein_314	hypothetical protein	-

Sequence

Protein

• Length: 336 a.a.
• Molecular weight: 37073.01 Da
• Isoelectric Point: 5.3212

>NTDB_id=352601 ES276_RS01615 WP_000990607.1 297995..299005(+) (ccpA) [Streptococcus pneumoniae strain TVO_1901936]
MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEVIDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFS
SLAKGIDDIAEMYKYNIVLANSDEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPS
VNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGITYSEGLVFESKYSYDDGYALAERLISSN
ATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSDDSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREV
LLPHGLTERSSTRKRK

Nucleotide

• Length: 1011 bp

>NTDB_id=352601 ES276_RS01615 WP_000990607.1 297995..299005(+) (ccpA) [Streptococcus pneumoniae strain TVO_1901936]
ATGAATGCAGATGATACAGTAACCATTTATGATGTCGCTCGTGAAGCAGGTGTTTCCATGGCGACGGTCAGCCGTGTGGT
CAATGGCAATAAAAATGTAAAAGAGAATACCCGTAAAAAAGTGCTAGAGGTAATTGATCGTTTGGATTATCGTCCAAATG
CAGTTGCGCGTGGTCTTGCAAGTAAAAAGACAACCACTGTCGGTGTCGTGATTCCAAATATTACCAATGGTTATTTTTCG
AGTTTGGCTAAGGGGATTGATGATATTGCAGAAATGTACAAGTACAATATTGTCCTAGCTAATAGCGATGAAGATAACGA
GAAAGAAGTTTCTGTTGTCAATACCCTCTTTTCAAAGCAGGTAGATGGCATTATCTATATGGGGTATCACTTGACAGATA
AAATTCGCTCAGAATTTTCGCGTTCACGTACTCCGATTGTTCTCGCAGGAACTGTCGATGTTGAGCACCAGTTGCCAAGT
GTCAATATTGACTATAAGCAAGCAACAATTGATGCAGTGAGTTACCTTGCTAAAGAAAATGAGCGTATTGCTTTCGTTAG
CGGTCCGCTAGTGGATGACATCAATGGTAAGGTTCGTTTAGTTGGCTACAAGGAAACCTTGAAAAAAGCAGGAATCACTT
ATAGTGAGGGTTTGGTATTTGAATCTAAATATAGCTATGATGATGGTTACGCCTTAGCAGAGCGTTTGATTTCATCAAAT
GCAACTGCAGCAGTTGTGACAGGTGATGAGTTGGCAGCAGGAGTCTTGAACGGTTTGGCTGATAAGGGTGTTTCTGTGCC
AGAAGATTTTGAAATTATTACTAGTGATGATTCACAAATCTCACGCTTTACCCGTCCAAACTTGACAACGATTGCCCAAC
CTCTTTATGACCTTGGTGCCATTAGTATGCGTATGTTGACCAAGATTATGCATAAGGAAGAGTTGGAAGAACGTGAAGTT
CTCTTACCTCATGGTTTGACAGAACGTAGCTCAACACGAAAACGTAAATAG

Domains

Predicted by InterproScan.

• Bacterial regulatory proteins, lacI family (LacI) (8-53)

• Periplasmic binding protein-like domain (Peripla_BP_3) (181-332)

3D structure

• AlphaFold DB: A0A0B7LZL8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccpA	Streptococcus pneumoniae D39	99.702	100	0.997
ccpA	Streptococcus gordonii str. Challis substr. CH1	87.126	99.405	0.866
ccpA	Lactococcus lactis subsp. lactis strain DGCC12653	57.704	98.512	0.568