Detailed information NTG0352186

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3306_RS09530
• Genome accession: NZ_CP038183
• Coordinates: 1950176..1951219 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MJ015
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1945176..1956219

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3306_RS09500 (E3306_09940)	-	1945594..1946850 (-)	1257	WP_001789555.1	aminopeptidase	-
E3306_RS09505 (E3306_09945)	-	1946853..1947053 (-)	201	WP_000180460.1	DUF1128 family protein	-
E3306_RS09510 (E3306_09950)	-	1947200..1947664 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3306_RS09515 (E3306_09955)	-	1947671..1947946 (+)	276	WP_000428171.1	hypothetical protein	-
E3306_RS09520 (E3306_09960)	-	1948224..1949441 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E3306_RS09525 (E3306_09965)	vraR	1949557..1950186 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3306_RS09530 (E3306_09970)	vraS	1950176..1951219 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3306_RS09535 (E3306_09975)	liaF	1951216..1951917 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3306_RS09540 (E3306_09980)	-	1951932..1952318 (-)	387	WP_001110179.1	hypothetical protein	-
E3306_RS09545 (E3306_09985)	map	1952535..1953293 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3306_RS09550 (E3306_09995)	-	1953824..1954810 (+)	987	WP_000999716.1	aromatic acid exporter family protein	-
E3306_RS09555 (E3306_10005)	-	1955300..1955713 (-)	414	WP_001670387.1	hypothetical protein	-
E3306_RS09560 (E3306_10010)	-	1955742..1955852 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=352186 E3306_RS09530 WP_001017131.1 1950176..1951219(-) (vraS) [Staphylococcus aureus strain MJ015]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=352186 E3306_RS09530 WP_001017131.1 1950176..1951219(-) (vraS) [Staphylococcus aureus strain MJ015]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1