Detailed information NTG0351472

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3I93_RS10220
• Genome accession: NZ_CP038021
• Coordinates: 2011518..2012561 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 04-002
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2006518..2017561

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3I93_RS10190 (E3I93_10190)	-	2006939..2008195 (-)	1257	WP_001793983.1	aminopeptidase	-
E3I93_RS10195 (E3I93_10195)	-	2008198..2008398 (-)	201	WP_000180460.1	DUF1128 family protein	-
E3I93_RS10200 (E3I93_10200)	-	2008545..2009009 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
E3I93_RS10205 (E3I93_10205)	-	2009016..2009291 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E3I93_RS10210 (E3I93_10210)	-	2009569..2010786 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
E3I93_RS10215 (E3I93_10215)	vraR	2010899..2011528 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3I93_RS10220 (E3I93_10220)	vraS	2011518..2012561 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3I93_RS10225 (E3I93_10225)	liaF	2012558..2013259 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3I93_RS10230 (E3I93_10230)	-	2013274..2013660 (-)	387	WP_001110178.1	hypothetical protein	-
E3I93_RS10235 (E3I93_10235)	map	2013877..2014635 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3I93_RS10250 (E3I93_10250)	-	2015335..2016321 (+)	987	WP_134521561.1	aromatic acid exporter family protein	-
E3I93_RS10255 (E3I93_10255)	-	2016510..2016923 (-)	414	WP_001643743.1	hypothetical protein	-
E3I93_RS10260 (E3I93_10260)	-	2016952..2017062 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=351472 E3I93_RS10220 WP_001017131.1 2011518..2012561(-) (vraS) [Staphylococcus aureus strain 04-002]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=351472 E3I93_RS10220 WP_001017131.1 2011518..2012561(-) (vraS) [Staphylococcus aureus strain 04-002]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1