Detailed information
Bioinformatically predicted
Overview
| Name | comE/blpR | Type | Regulator |
| Locus tag | E3C75_RS02995 | Genome accession | NZ_CP038020 |
| Coordinates | 559356..560096 (+) | Length | 246 a.a. |
| NCBI ID | WP_111679174.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain ATCC 19258 | ||
| Function | activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 526786..606173 | 559356..560096 | within | 0 |
Gene organization within MGE regions
Location: 526786..606173
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3C75_RS02880 | - | 530913..531104 (+) | 192 | WP_100262165.1 | calcium-binding protein | - |
| E3C75_RS02885 | - | 531088..531639 (+) | 552 | WP_111679142.1 | hypothetical protein | - |
| E3C75_RS02890 | - | 531688..537150 (+) | 5463 | WP_111679144.1 | SNF2-related protein | - |
| E3C75_RS02895 | - | 537648..539426 (+) | 1779 | WP_111679146.1 | reverse transcriptase/maturase family protein | - |
| E3C75_RS02900 | - | 539519..540907 (+) | 1389 | Protein_529 | helicase-related protein | - |
| E3C75_RS02905 | - | 540978..541277 (+) | 300 | WP_111679148.1 | DUF5962 family protein | - |
| E3C75_RS02910 | - | 541291..541581 (+) | 291 | WP_111679150.1 | DUF5966 family protein | - |
| E3C75_RS02915 | - | 541875..543497 (+) | 1623 | WP_111679152.1 | AAA family ATPase | - |
| E3C75_RS02920 | - | 543494..544822 (+) | 1329 | WP_111679154.1 | HNH endonuclease signature motif containing protein | - |
| E3C75_RS02925 | - | 545085..545723 (+) | 639 | WP_111679156.1 | peptidylprolyl isomerase | - |
| E3C75_RS02930 | - | 545763..546838 (+) | 1076 | Protein_535 | DNA primase | - |
| E3C75_RS02935 | - | 546892..547119 (+) | 228 | WP_111679158.1 | DUF5965 family protein | - |
| E3C75_RS02940 | - | 547116..547505 (+) | 390 | WP_039670295.1 | DUF5945 family protein | - |
| E3C75_RS02945 | - | 547552..547842 (+) | 291 | WP_162173398.1 | hypothetical protein | - |
| E3C75_RS02950 | - | 547978..549303 (+) | 1326 | Protein_539 | IS1182 family transposase | - |
| E3C75_RS11450 | pezA | 549499..549975 (+) | 477 | WP_039670297.1 | type II toxin-antitoxin system antitoxin PezA | - |
| E3C75_RS02955 | pezT | 549975..550751 (+) | 777 | WP_111679164.1 | type II toxin-antitoxin system toxin PezT | - |
| E3C75_RS02960 | - | 550735..551544 (+) | 810 | WP_039670299.1 | Hachiman antiphage defense system protein HamA | - |
| E3C75_RS02965 | - | 551541..554624 (+) | 3084 | WP_111679166.1 | DEAD/DEAH box helicase | - |
| E3C75_RS02970 | - | 554649..555545 (+) | 897 | WP_133264092.1 | restriction endonuclease | - |
| E3C75_RS02975 | - | 555886..556248 (+) | 363 | WP_111679170.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| E3C75_RS02980 | mobC | 556251..556616 (+) | 366 | WP_039671039.1 | plasmid mobilization relaxosome protein MobC | - |
| E3C75_RS02985 | - | 556603..558486 (+) | 1884 | WP_111679172.1 | SAG1250 family conjugative relaxase | - |
| E3C75_RS02990 | - | 559013..559354 (+) | 342 | WP_024404826.1 | LytTR family DNA-binding domain-containing protein | - |
| E3C75_RS02995 | comE/blpR | 559356..560096 (+) | 741 | WP_111679174.1 | response regulator transcription factor | Regulator |
| E3C75_RS03000 | - | 560107..561447 (+) | 1341 | WP_039671036.1 | GHKL domain-containing protein | - |
| E3C75_RS03005 | - | 561495..561650 (-) | 156 | WP_096811960.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| E3C75_RS03010 | - | 561749..563110 (-) | 1362 | WP_111679175.1 | bacteriocin secretion accessory protein | - |
| E3C75_RS03015 | - | 563122..565276 (-) | 2155 | Protein_553 | peptide cleavage/export ABC transporter | - |
| E3C75_RS03020 | - | 565574..565831 (+) | 258 | WP_039671027.1 | Blp family class II bacteriocin | - |
| E3C75_RS03025 | - | 565848..566027 (+) | 180 | WP_111679177.1 | class IIb bacteriocin, lactobin A/cerein 7B family | - |
| E3C75_RS03030 | - | 566629..567979 (+) | 1351 | Protein_556 | IS3 family transposase | - |
| E3C75_RS03035 | - | 568403..569428 (+) | 1026 | WP_111679179.1 | thioredoxin fold domain-containing protein | - |
| E3C75_RS03040 | - | 569432..570127 (+) | 696 | WP_111679181.1 | type II CAAX endopeptidase family protein | - |
| E3C75_RS03045 | - | 570157..570309 (+) | 153 | WP_162173399.1 | hypothetical protein | - |
| E3C75_RS03050 | - | 570495..570890 (+) | 396 | WP_111679183.1 | sigma-70 family RNA polymerase sigma factor | - |
| E3C75_RS11090 | - | 571208..571348 (+) | 141 | WP_044775899.1 | hypothetical protein | - |
| E3C75_RS03055 | - | 571447..573021 (+) | 1575 | WP_111679185.1 | recombinase family protein | - |
| E3C75_RS03060 | - | 573021..574640 (+) | 1620 | WP_111679187.1 | recombinase family protein | - |
| E3C75_RS03065 | - | 574633..576072 (+) | 1440 | WP_133264091.1 | recombinase family protein | - |
| E3C75_RS12095 | - | 576093..576494 (+) | 402 | Protein_565 | NUDIX hydrolase | - |
| E3C75_RS03075 | prmA | 576494..577447 (+) | 954 | WP_084828438.1 | 50S ribosomal protein L11 methyltransferase | - |
| E3C75_RS03080 | - | 577448..578191 (+) | 744 | WP_084825734.1 | 16S rRNA (uracil(1498)-N(3))-methyltransferase | - |
| E3C75_RS03085 | - | 578375..580951 (+) | 2577 | Protein_568 | bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase | - |
| E3C75_RS03090 | nrdI | 580938..581396 (-) | 459 | WP_084828439.1 | class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI | - |
| E3C75_RS03095 | - | 581565..583784 (+) | 2220 | WP_084828440.1 | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | - |
| E3C75_RS03100 | dtd | 583797..584240 (+) | 444 | WP_084828441.1 | D-aminoacyl-tRNA deacylase | - |
| E3C75_RS11970 | - | 584681..584965 (+) | 285 | WP_065972829.1 | glycoside hydrolase family 66 protein | - |
| E3C75_RS11975 | - | 584895..585146 (+) | 252 | Protein_573 | glycoside hydrolase family 66 protein | - |
| E3C75_RS11465 | - | 585230..585409 (+) | 180 | WP_223899617.1 | hypothetical protein | - |
| E3C75_RS11470 | - | 585605..585823 (+) | 219 | WP_223899612.1 | hypothetical protein | - |
| E3C75_RS11475 | - | 585842..586216 (+) | 375 | WP_223899613.1 | hypothetical protein | - |
| E3C75_RS03120 | ilvA | 586517..587767 (+) | 1251 | WP_111679191.1 | threonine ammonia-lyase IlvA | - |
| E3C75_RS03125 | def | 587928..588542 (-) | 615 | WP_002949244.1 | peptide deformylase | - |
| E3C75_RS03130 | - | 588636..589274 (-) | 639 | WP_100273462.1 | cyclic nucleotide-binding domain-containing protein | - |
| E3C75_RS03135 | - | 589381..590544 (+) | 1164 | WP_100273463.1 | MFS transporter | - |
| E3C75_RS03140 | rpsO | 590693..590962 (+) | 270 | WP_002949247.1 | 30S ribosomal protein S15 | - |
| E3C75_RS03145 | - | 591192..591773 (-) | 582 | WP_011225359.1 | VanZ family protein | - |
| E3C75_RS11095 | - | 592342..592512 (+) | 171 | WP_167740656.1 | hypothetical protein | - |
| E3C75_RS03150 | - | 592599..592706 (+) | 108 | WP_081247985.1 | LPXTG cell wall anchor domain-containing protein | - |
| E3C75_RS03155 | - | 592793..593533 (-) | 741 | WP_002949253.1 | amino acid ABC transporter ATP-binding protein | - |
| E3C75_RS03160 | - | 593533..595083 (-) | 1551 | WP_011680665.1 | ABC transporter substrate-binding protein/permease | - |
| E3C75_RS03165 | - | 595286..596140 (+) | 855 | WP_011680666.1 | undecaprenyl-diphosphate phosphatase | - |
| E3C75_RS03170 | - | 596192..596500 (-) | 309 | WP_306496352.1 | DUF3021 family protein | - |
| E3C75_RS03175 | mecA | 596777..597526 (+) | 750 | WP_100273348.1 | adaptor protein MecA | Regulator |
| E3C75_RS03180 | - | 597530..598687 (+) | 1158 | WP_100262326.1 | MraY family glycosyltransferase | - |
| E3C75_RS03185 | sufC | 598848..599618 (+) | 771 | WP_002947634.1 | Fe-S cluster assembly ATPase SufC | - |
| E3C75_RS03190 | sufD | 599655..600917 (+) | 1263 | WP_011680669.1 | Fe-S cluster assembly protein SufD | - |
| E3C75_RS03195 | - | 600971..602203 (+) | 1233 | WP_046206385.1 | cysteine desulfurase | - |
| E3C75_RS03200 | sufU | 602190..602624 (+) | 435 | WP_111679194.1 | Fe-S cluster assembly sulfur transfer protein SufU | - |
| E3C75_RS03205 | sufB | 602704..604122 (+) | 1419 | WP_002947647.1 | Fe-S cluster assembly protein SufB | - |
| E3C75_RS03210 | - | 604406..605485 (+) | 1080 | Protein_596 | peptide ABC transporter substrate-binding protein | - |
| E3C75_RS03215 | - | 605487..605705 (+) | 219 | Protein_597 | ABC transporter permease subunit | - |
Sequence
Protein
Download Length: 246 a.a. Molecular weight: 28890.15 Da Isoelectric Point: 7.2201
>NTDB_id=351392 E3C75_RS02995 WP_111679174.1 559356..560096(+) (comE/blpR) [Streptococcus thermophilus strain ATCC 19258]
MNIFIIEDDFMQQARIEKIITKLLEKHNIVPKKFEISGKPHQLLQAIEEKGVHQLFFLDIEIKEDELKGLQVAKQIREID
PYASIVFVTTHSEFMPLSFRYQVSALDYIDKELGVTEFESRIEAALLHTHNKDNSAVSDDSFYFKSKYAQVQYPFNEVYY
IETSPRPHRVILYTKTDRMEFTASLSDILKQDKRLVQCHRSFAINPRNVVKVDRNEKQIYFPNGATCFISRQKLESTLAV
IDRLHR
MNIFIIEDDFMQQARIEKIITKLLEKHNIVPKKFEISGKPHQLLQAIEEKGVHQLFFLDIEIKEDELKGLQVAKQIREID
PYASIVFVTTHSEFMPLSFRYQVSALDYIDKELGVTEFESRIEAALLHTHNKDNSAVSDDSFYFKSKYAQVQYPFNEVYY
IETSPRPHRVILYTKTDRMEFTASLSDILKQDKRLVQCHRSFAINPRNVVKVDRNEKQIYFPNGATCFISRQKLESTLAV
IDRLHR
Nucleotide
Download Length: 741 bp
>NTDB_id=351392 E3C75_RS02995 WP_111679174.1 559356..560096(+) (comE/blpR) [Streptococcus thermophilus strain ATCC 19258]
ATGAATATCTTTATAATAGAAGATGATTTTATGCAACAAGCGAGAATTGAGAAGATTATTACTAAGCTGTTAGAAAAGCA
CAACATCGTTCCGAAAAAATTTGAAATTTCAGGAAAACCTCATCAGCTACTTCAAGCAATAGAAGAAAAAGGAGTACATC
AGCTCTTCTTTTTAGATATTGAGATTAAGGAAGACGAACTAAAAGGACTTCAAGTCGCTAAACAAATTAGAGAGATTGAC
CCTTATGCTAGTATTGTTTTTGTGACAACACACTCCGAGTTTATGCCCTTATCTTTCAGGTACCAGGTATCTGCCTTGGA
CTATATTGACAAAGAGCTTGGAGTTACCGAATTTGAATCGCGAATAGAAGCAGCTTTACTTCATACTCACAATAAGGACA
ATAGCGCCGTATCGGATGATTCATTCTATTTTAAGTCCAAATATGCTCAAGTACAATACCCATTCAATGAAGTGTACTAC
ATCGAGACTTCTCCCCGCCCTCATCGTGTTATCCTTTATACCAAGACAGACCGAATGGAGTTCACAGCAAGTTTGTCAGA
CATTTTGAAACAAGATAAACGACTTGTACAATGTCATCGTTCGTTTGCAATCAATCCGAGGAATGTTGTTAAAGTGGATA
GAAATGAAAAACAGATCTACTTTCCTAATGGAGCCACCTGTTTTATTTCAAGGCAAAAGCTAGAATCAACTTTAGCTGTT
ATTGATAGACTGCATAGATAA
ATGAATATCTTTATAATAGAAGATGATTTTATGCAACAAGCGAGAATTGAGAAGATTATTACTAAGCTGTTAGAAAAGCA
CAACATCGTTCCGAAAAAATTTGAAATTTCAGGAAAACCTCATCAGCTACTTCAAGCAATAGAAGAAAAAGGAGTACATC
AGCTCTTCTTTTTAGATATTGAGATTAAGGAAGACGAACTAAAAGGACTTCAAGTCGCTAAACAAATTAGAGAGATTGAC
CCTTATGCTAGTATTGTTTTTGTGACAACACACTCCGAGTTTATGCCCTTATCTTTCAGGTACCAGGTATCTGCCTTGGA
CTATATTGACAAAGAGCTTGGAGTTACCGAATTTGAATCGCGAATAGAAGCAGCTTTACTTCATACTCACAATAAGGACA
ATAGCGCCGTATCGGATGATTCATTCTATTTTAAGTCCAAATATGCTCAAGTACAATACCCATTCAATGAAGTGTACTAC
ATCGAGACTTCTCCCCGCCCTCATCGTGTTATCCTTTATACCAAGACAGACCGAATGGAGTTCACAGCAAGTTTGTCAGA
CATTTTGAAACAAGATAAACGACTTGTACAATGTCATCGTTCGTTTGCAATCAATCCGAGGAATGTTGTTAAAGTGGATA
GAAATGAAAAACAGATCTACTTTCCTAATGGAGCCACCTGTTTTATTTCAAGGCAAAAGCTAGAATCAACTTTAGCTGTT
ATTGATAGACTGCATAGATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comE/blpR | Streptococcus mutans UA159 |
53.306 |
98.374 |
0.524 |
| comE/comE1 | Streptococcus equinus JB1 |
41.841 |
97.154 |
0.407 |