Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   GL189_RS02780 Genome accession   NZ_CP046360
Coordinates   543661..545508 (+) Length   615 a.a.
NCBI ID   WP_024477906.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 574     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 538661..550508
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL189_RS02760 (GL189_02835) - 539493..540272 (+) 780 WP_000290025.1 alpha/beta hydrolase -
  GL189_RS02765 (GL189_02840) murM 540384..541604 (+) 1221 WP_001816673.1 peptidoglycan bridge formation alanyltransferase MurM -
  GL189_RS02770 (GL189_02845) murN 541609..542841 (+) 1233 WP_001229519.1 peptidoglycan bridge formation alanyltransferase MurN -
  GL189_RS02775 (GL189_02850) - 542920..543621 (+) 702 WP_001267410.1 M57 family metalloprotease -
  GL189_RS02780 (GL189_02855) uvrC 543661..545508 (+) 1848 WP_024477906.1 excinuclease ABC subunit UvrC Machinery gene
  GL189_RS02785 (GL189_02860) - 545498..546331 (+) 834 Protein_559 metallophosphoesterase family protein -
  GL189_RS02790 (GL189_02865) - 546515..547315 (-) 801 WP_000714633.1 amino acid ABC transporter substrate-binding protein -
  GL189_RS02795 (GL189_02870) - 547486..548091 (+) 606 WP_000670163.1 nitroreductase family protein -
  GL189_RS02800 (GL189_02875) pepV 548104..549504 (+) 1401 WP_000125044.1 dipeptidase PepV -
  GL189_RS02805 (GL189_02880) - 549558..550136 (+) 579 WP_000078149.1 uracil-DNA glycosylase family protein -

Sequence

Protein


Download         Length: 615 a.a.        Molecular weight: 70583.19 Da        Isoelectric Point: 9.2183

>NTDB_id=351330 GL189_RS02780 WP_024477906.1 543661..545508(+) (uvrC) [Streptococcus pneumoniae strain 574]
MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSYFRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEIN
LIKENKPKYNIMLKDDKSYPFIKITNERYPRLIITRQVKKDGSLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
YYHIGQCMAHTICKKDEAYFKSMAQEVSDFLKGQDNKIIDELKGKMAAAAQTMEFERAAEYRDLIQAIGTLRTKQRVMAK
DLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNLFPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKAL
VDSKILKPQRGEKKQLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGTSPVSAMVV
FVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLIVIDGGQGQVNIAKQVIQEELGLDIPIAGLQ
KNDKHQTHELLFGDPLEVVDLSRNSQEFFLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMRHFKSL
TKIKEASVDEIVEVGVPRAVAEAVQTKLNPQETEILLQVAEERVDYQTEGNHNKP

Nucleotide


Download         Length: 1848 bp        

>NTDB_id=351330 GL189_RS02780 WP_024477906.1 543661..545508(+) (uvrC) [Streptococcus pneumoniae strain 574]
ATGAACAACTTGATTAAATCAAAACTAGAGCTCTTGCCGACCAGCCCTGGTTGCTACATTCATAAGGATAAAAATGGCAC
CATTATCTATGTAGGAAAGGCTAAAAATCTGCGTAATCGAGTACGGTCCTATTTTCGTGGAAGTCATGATACCAAGACAG
AGGCTCTGGTGTCTGAAATTGTGGATTTTGAATTTATTGTTACGGAGTCTAATATTGAGGCACTTCTCCTAGAAATCAAC
CTGATCAAGGAAAACAAGCCCAAGTACAATATCATGCTCAAGGATGACAAGTCCTATCCTTTCATCAAAATCACCAATGA
GCGCTATCCACGCTTGATTATCACTCGTCAGGTCAAAAAGGACGGAAGTCTTTATTTTGGACCCTATCCCGATGTGGGGG
CAGCCAATGAAATCAAGCGGTTGCTGGATCGGATATTCCCTTTTCGTAAGTGTACCAACCCGCCCTCTAAGGTCTGTTTT
TATTACCATATCGGTCAATGCATGGCCCACACCATCTGTAAGAAGGATGAGGCTTATTTCAAGTCTATGGCCCAGGAGGT
TTCTGATTTTCTGAAAGGGCAGGATAACAAAATCATTGATGAGCTAAAGGGCAAAATGGCAGCGGCAGCCCAGACTATGG
AGTTTGAACGTGCGGCGGAATACCGTGACCTGATTCAGGCTATTGGAACGCTTCGAACCAAGCAACGGGTCATGGCTAAG
GATCTCCAAAATCGCGATGTCTTTGGCTACTATGTGGATAAGGGCTGGATGTGTGTGCAGGTTTTCTTTGTCCGTCAGGG
TAAGCTCATCGAGCGCGATGTCAATCTCTTCCCCTACTTCAATGATCCAGATGAGGATTTTTTGACCTATGTAGGACAAT
TCTATCAAGAAAAATCCCATCTAGTTCCCAATGAGGTACTGATTCCGCAAGATATTGACGAAGAGGCTGTCAAGGCCTTG
GTGGATTCCAAGATTCTTAAGCCTCAACGTGGAGAGAAAAAGCAGCTGGTCAATTTAGCTATAAAAAATGCCCGTGTTAG
CCTAGAGCAGAAGTTCAACCTGCTAGAGAAATCTGTCGAGAAGACCCAAGGAGCTATTGAAAATCTAGGACGCTTGCTTC
AAATCCCAACCCCAGTTCGCATCGAGTCCTTCGATAACTCCAATATCATGGGAACTAGTCCTGTTTCAGCCATGGTGGTC
TTTGTCAACGGCAAGCCTAGTAAGAAGGATTACCGTAAGTATAAAATCAAGACCGTAGTCGGGCCAGACGACTATGCCAG
TATGCGAGAGGTCATTCGCAGACGCTATGGTCGAGTACAGCGTGAGGCTTTGACTCCTCCAGATTTGATTGTGATTGATG
GGGGGCAAGGTCAAGTCAATATTGCTAAGCAAGTCATCCAAGAAGAACTGGGCTTGGATATTCCAATTGCAGGTCTGCAA
AAGAATGATAAGCACCAAACCCATGAATTGCTCTTTGGAGATCCGCTGGAAGTGGTGGACTTGTCTCGCAATTCTCAGGA
ATTTTTCCTCCTCCAACGCATTCAAGATGAGGTCCACCGCTTTGCCATTACCTTCCACCGCCAACTGCGCTCCAAAAATT
CTTTCTCATCTCAATTGGATGGGATTGATGGTCTGGGACCTAAACGCAAGCAAAATCTCATGAGGCACTTCAAGTCTCTG
ACCAAAATCAAGGAAGCCAGTGTGGATGAGATTGTCGAAGTTGGAGTACCAAGAGCAGTAGCAGAGGCTGTGCAAACCAA
GTTGAACCCGCAGGAAACAGAAATCTTGCTTCAAGTGGCGGAAGAAAGAGTAGATTACCAAACGGAAGGAAACCACAATA
AACCATAA

Domains

Predicted by InterProScan.

UvrB/uvrC motif (UVR)

(197-228)

GIY-YIG catalytic domain (GIY-YIG)

(17-90)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(372-523)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae R6

98.049

100

0.98
  uvrC Streptococcus pneumoniae D39

98.049

100

0.98
  uvrC Streptococcus pneumoniae TIGR4

97.724

100

0.977