Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   MGAS15252_RS05950 Genome accession   NC_017040
Coordinates   1220473..1221114 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes MGAS15252     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1215473..1226114
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS05925 (MGAS15252_1223) comFA/cflA 1215559..1216884 (-) 1326 WP_014407739.1 DEAD/DEAH box helicase Machinery gene
  MGAS15252_RS05930 (MGAS15252_1224) - 1216940..1217572 (+) 633 WP_009880468.1 YigZ family protein -
  MGAS15252_RS05935 (MGAS15252_1225) cysK 1217700..1218641 (+) 942 WP_011888673.1 cysteine synthase A -
  MGAS15252_RS05940 (MGAS15252_1226) - 1218659..1219036 (-) 378 WP_009880466.1 S1 RNA-binding domain-containing protein -
  MGAS15252_RS05945 (MGAS15252_1227) - 1219036..1220436 (-) 1401 WP_014407740.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  MGAS15252_RS05950 (MGAS15252_1228) vraR 1220473..1221114 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  MGAS15252_RS05955 (MGAS15252_1229) - 1221107..1222111 (-) 1005 WP_002991890.1 sensor histidine kinase -
  MGAS15252_RS05960 (MGAS15252_1230) liaF 1222108..1222800 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  MGAS15252_RS05965 (MGAS15252_1231) pknB 1222923..1224821 (-) 1899 WP_012560855.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  MGAS15252_RS05970 (MGAS15252_1232) - 1224818..1225558 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=35068 MGAS15252_RS05950 WP_002983671.1 1220473..1221114(-) (vraR) [Streptococcus pyogenes MGAS15252]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=35068 MGAS15252_RS05950 WP_002983671.1 1220473..1221114(-) (vraR) [Streptococcus pyogenes MGAS15252]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTAGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCCATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment