Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HELPY_RS02610 Genome accession   NC_012973
Coordinates   525446..527230 (-) Length   594 a.a.
NCBI ID   WP_000774308.1    Uniprot ID   -
Organism   Helicobacter pylori B38     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 520446..532230
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HELPY_RS02580 (HELPY_0528) - 520820..521068 (+) 249 WP_000790557.1 RNA-binding protein -
  HELPY_RS02585 (HELPY_0529) - 521298..522119 (-) 822 WP_001263349.1 glycosyltransferase family 25 protein -
  HELPY_RS02590 (HELPY_0531) trxB 522476..523411 (-) 936 WP_000564414.1 thioredoxin-disulfide reductase -
  HELPY_RS02595 (HELPY_0532) trxA 523416..523736 (-) 321 WP_000020199.1 thioredoxin -
  HELPY_RS02600 (HELPY_0533) - 523825..524169 (-) 345 WP_001211672.1 YraN family protein -
  HELPY_RS02605 (HELPY_0534) - 524170..525435 (-) 1266 WP_000746744.1 homoserine dehydrogenase -
  HELPY_RS02610 (HELPY_0535) uvrC 525446..527230 (-) 1785 WP_000774308.1 excinuclease ABC subunit UvrC Machinery gene
  HELPY_RS02615 (HELPY_0536) - 527231..527692 (-) 462 WP_000437225.1 hypothetical protein -
  HELPY_RS02620 - 527684..527863 (+) 180 WP_000468793.1 hypothetical protein -
  HELPY_RS02625 (HELPY_0538) - 527875..528516 (-) 642 WP_000659448.1 ATP-binding cassette domain-containing protein -
  HELPY_RS02630 (HELPY_0539) - 528520..530181 (-) 1662 WP_041200395.1 ABC transporter permease/substrate-binding protein -
  HELPY_RS02635 (HELPY_0540) - 530250..530687 (-) 438 WP_041200504.1 hypothetical protein -
  HELPY_RS02640 (HELPY_0541) motB 530693..531466 (-) 774 WP_001085343.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68654.93 Da        Isoelectric Point: 9.7880

>NTDB_id=34843 HELPY_RS02610 WP_000774308.1 525446..527230(-) (uvrC) [Helicobacter pylori B38]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEIMPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKKEYLKIAKKCLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNEALKELQEFISHQYSKKIALNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPGNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=34843 HELPY_RS02610 WP_000774308.1 525446..527230(-) (uvrC) [Helicobacter pylori B38]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAACAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAAGCAAAAAACTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAACAATGAAATCATGCCCA
ACCATCGCGCAAGCTTACGAATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGAGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AAAAGAGTATTTAAAAATCGCTAAAAAATGTTTAGAAATGATTGAAAATAAAGACAGACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAGCAATTTGCGTTTTGAAGAAGCTCTCATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGTGGGAACAACAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CCGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATTCTATTAAAC
GCTTGCTCTAATGAAGCGCTTAAAGAATTGCAAGAGTTTATCTCCCATCAATATTCTAAAAAAATCGCTCTTAATATCCC
TAAAAAAGGCGATAAGCTCGCTCTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAACGCCTTCCAAAAAAATTCTTATCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGATCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTGGCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTGAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.965

99.832

0.968

Multiple sequence alignment