Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   EXA24_RS04185 Genome accession   NZ_CP036376
Coordinates   774889..776238 (+) Length   449 a.a.
NCBI ID   WP_001065469.1    Uniprot ID   R4ZB13
Organism   Streptococcus agalactiae strain Sag153     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 769889..781238
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EXA24_RS04155 (EXA24_04295) - 770294..770860 (+) 567 WP_000592391.1 PepSY domain-containing protein -
  EXA24_RS04160 (EXA24_04300) - 770909..771559 (-) 651 WP_000100031.1 amino acid ABC transporter permease -
  EXA24_RS04165 (EXA24_04305) - 771571..772266 (-) 696 WP_000173642.1 amino acid ABC transporter permease -
  EXA24_RS04170 (EXA24_04310) - 772279..773079 (-) 801 WP_000946165.1 transporter substrate-binding domain-containing protein -
  EXA24_RS04175 (EXA24_04315) - 773091..773846 (-) 756 WP_000053145.1 amino acid ABC transporter ATP-binding protein -
  EXA24_RS04180 (EXA24_04320) vicR 774186..774896 (+) 711 WP_000722052.1 response regulator YycF Regulator
  EXA24_RS04185 (EXA24_04325) vicK 774889..776238 (+) 1350 WP_001065469.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EXA24_RS04190 (EXA24_04330) vicX 776242..777051 (+) 810 WP_001289497.1 MBL fold metallo-hydrolase Regulator
  EXA24_RS04195 (EXA24_04335) - 777054..777422 (+) 369 WP_000719384.1 YbaN family protein -
  EXA24_RS04200 (EXA24_04340) rnc 777598..778284 (+) 687 WP_000661526.1 ribonuclease III -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51059.13 Da        Isoelectric Point: 4.8621

>NTDB_id=348286 EXA24_RS04185 WP_001065469.1 774889..776238(+) (vicK) [Streptococcus agalactiae strain Sag153]
MNNSAANIRSFELALLFLLVFVAVYFVYLAVRDFKMSKNIRLLNWKVRDLIAGNYSDSILIQGDADLVELGESLNDLSDV
FRMAHDNLEQEKNRLASILTYMTDGVLATDRSGKIVMINETAQQQFNLAYDEALSMNIVDMLGSGSPYSFQDLVSKTPEV
VLNRRDENGEFVTLRIRFALNRRESGFISGLVAVSHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALNE
EVAPSFIKVSLDETNRMMRMISDLLSLSRIDNEVTHLDVEMTNFTAFMTSILNRFDQIRNQKTVTGKVYEIVRDYPLKSI
WVEIDTDKMTQVIDNILNNAVKYSPDGGKITVNLRTTKTQMILSISDQGLGIPKKDLPLIFDRFYRVDKARSRQQGGTGL
GLSIAKEIVKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVTYEEWEDVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=348286 EXA24_RS04185 WP_001065469.1 774889..776238(+) (vicK) [Streptococcus agalactiae strain Sag153]
ATGAATAATAGTGCTGCAAATATTAGGTCGTTTGAGCTAGCCTTACTTTTTTTACTAGTTTTTGTTGCTGTTTATTTTGT
TTATCTAGCGGTTAGAGATTTTAAAATGTCTAAAAATATCCGGCTTTTGAATTGGAAAGTCAGAGATTTGATAGCAGGAA
ATTATTCAGATAGTATTCTAATTCAAGGTGATGCAGATTTGGTAGAATTAGGTGAAAGTCTAAATGATTTATCTGATGTC
TTCCGAATGGCACATGATAACTTAGAACAAGAAAAGAATCGCTTAGCAAGTATCTTAACTTATATGACTGACGGTGTGCT
GGCTACAGATCGTTCAGGAAAAATCGTTATGATTAATGAGACAGCCCAACAGCAGTTCAATCTAGCATATGATGAAGCTT
TATCAATGAATATTGTTGATATGTTAGGGTCGGGAAGTCCATATTCGTTCCAAGATTTAGTCTCTAAAACGCCAGAGGTA
GTTCTTAATAGACGTGATGAAAACGGTGAATTTGTTACCTTACGGATTCGATTTGCTTTGAACCGTCGTGAAAGTGGTTT
TATTTCCGGTTTAGTTGCAGTGTCACACGATGCTACTGAGCAAGAGAAAGAAGAGCGTGAAAGAAGACTTTTTGTATCTA
ATGTTTCTCATGAACTTCGTACACCTTTGACATCTGTAAAATCTTATTTAGAAGCTTTAGATGAGGGAGCGCTTAATGAA
GAAGTTGCTCCAAGCTTCATTAAGGTATCTCTAGATGAAACAAATCGTATGATGCGTATGATATCAGATTTATTAAGTTT
ATCGCGCATTGATAATGAAGTAACGCATTTAGATGTTGAAATGACGAATTTTACAGCTTTCATGACCTCAATTTTGAATC
GATTTGATCAGATTAGAAATCAAAAAACAGTCACAGGAAAAGTTTATGAAATTGTCAGAGATTATCCTCTTAAGTCAATT
TGGGTGGAAATTGATACAGATAAGATGACTCAAGTGATTGATAACATTTTAAATAATGCAGTCAAGTATTCACCAGATGG
TGGTAAGATCACAGTTAATCTACGCACAACTAAAACGCAGATGATTTTATCAATATCAGACCAAGGCTTAGGTATTCCCA
AAAAAGATTTACCTCTCATCTTTGATCGTTTTTATCGTGTTGATAAGGCGAGAAGTCGTCAACAGGGTGGGACTGGACTT
GGTTTGTCAATTGCAAAAGAAATTGTTAAGCAGCATAAGGGATTTATTTGGGCTAAGAGTGAGTATGGTAAAGGGTCTAC
TTTTACAATAGTCTTGCCTTATGATAAAGATGCTGTAACTTATGAAGAATGGGAGGACGTTGAAGATTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)

PAS fold (PAS)

(94-180)

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB R4ZB13

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

74.576

91.982

0.686
  micB Streptococcus pneumoniae Cp1015

67.436

96.437

0.65

Multiple sequence alignment