Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   ERW13_RS10330 Genome accession   NZ_CP035791
Coordinates   2002993..2004342 (+) Length   449 a.a.
NCBI ID   WP_000815646.1    Uniprot ID   Q9XB96
Organism   Staphylococcus aureus strain 592     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2002993..2024322 2002993..2004342 within 0


Gene organization within MGE regions


Location: 2002993..2024322
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ERW13_RS10330 ccrA 2002993..2004342 (+) 1350 WP_000815646.1 recombinase family protein Machinery gene
  ERW13_RS10335 ccrB 2004364..2005992 (+) 1629 WP_001186602.1 recombinase family protein Machinery gene
  ERW13_RS10340 - 2006510..2006860 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  ERW13_RS10345 - 2006947..2007258 (+) 312 WP_000700853.1 DUF960 family protein -
  ERW13_RS10350 - 2007276..2007782 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  ERW13_RS10355 - 2007803..2008120 (+) 318 WP_000659050.1 JAB domain-containing protein -
  ERW13_RS10360 - 2008239..2009324 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  ERW13_RS10365 - 2009321..2011213 (+) 1893 WP_001557544.1 site-specific integrase -
  ERW13_RS10370 - 2011220..2011597 (+) 378 WP_000361059.1 DUF6262 family protein -
  ERW13_RS10375 - 2011748..2012530 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  ERW13_RS10380 erm(A) 2012656..2013387 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  ERW13_RS10395 - 2013885..2014547 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  ERW13_RS10405 - 2014892..2015530 (-) 639 Protein_1937 sulfite exporter TauE/SafE family protein -
  ERW13_RS10410 cstR 2015530..2015790 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  ERW13_RS10415 - 2015926..2016990 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  ERW13_RS10420 cstB 2017023..2018357 (+) 1335 Protein_1940 persulfide dioxygenase-sulfurtransferase CstB -
  ERW13_RS10430 - 2018471..2019580 (-) 1110 WP_000943131.1 ROK family transcriptional regulator -
  ERW13_RS10435 psm-mec 2019935..2020003 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  ERW13_RS10440 mecI 2020088..2020459 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  ERW13_RS10445 mecR1 2020459..2022216 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  ERW13_RS10450 mecA 2022313..2024322 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52607.20 Da        Isoelectric Point: 9.9585

>NTDB_id=344454 ERW13_RS10330 WP_000815646.1 2002993..2004342(+) (ccrA) [Staphylococcus aureus strain 592]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=344454 ERW13_RS10330 WP_000815646.1 2002993..2004342(+) (ccrA) [Staphylococcus aureus strain 592]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9XB96

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

100

100

1
  ccrA Staphylococcus aureus COL

74.833

100

0.748

Multiple sequence alignment