Detailed information NTG0344455

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: ERW13_RS10335
• Genome accession: NZ_CP035791
• Coordinates: 2004364..2005992 (+)
• Length: 542 a.a.
• NCBI ID: WP_001186602.1
• Uniprot ID: Q9XB94
• Organism: Staphylococcus aureus strain 592
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2002993..2024322	2004364..2005992	within	0

Gene organization within MGE regions

Location: 2002993..2024322

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ERW13_RS10330	ccrA	2002993..2004342 (+)	1350	WP_000815646.1	recombinase family protein	Machinery gene
ERW13_RS10335	ccrB	2004364..2005992 (+)	1629	WP_001186602.1	recombinase family protein	Machinery gene
ERW13_RS10340	-	2006510..2006860 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
ERW13_RS10345	-	2006947..2007258 (+)	312	WP_000700853.1	DUF960 family protein	-
ERW13_RS10350	-	2007276..2007782 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
ERW13_RS10355	-	2007803..2008120 (+)	318	WP_000659050.1	JAB domain-containing protein	-
ERW13_RS10360	-	2008239..2009324 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
ERW13_RS10365	-	2009321..2011213 (+)	1893	WP_001557544.1	site-specific integrase	-
ERW13_RS10370	-	2011220..2011597 (+)	378	WP_000361059.1	DUF6262 family protein	-
ERW13_RS10375	-	2011748..2012530 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
ERW13_RS10380	erm(A)	2012656..2013387 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
ERW13_RS10395	-	2013885..2014547 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
ERW13_RS10405	-	2014892..2015530 (-)	639	Protein_1937	sulfite exporter TauE/SafE family protein	-
ERW13_RS10410	cstR	2015530..2015790 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
ERW13_RS10415	-	2015926..2016990 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
ERW13_RS10420	cstB	2017023..2018357 (+)	1335	Protein_1940	persulfide dioxygenase-sulfurtransferase CstB	-
ERW13_RS10430	-	2018471..2019580 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
ERW13_RS10435	psm-mec	2019935..2020003 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
ERW13_RS10440	mecI	2020088..2020459 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
ERW13_RS10445	mecR1	2020459..2022216 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
ERW13_RS10450	mecA	2022313..2024322 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62664.84 Da
• Isoelectric Point: 9.8600

>NTDB_id=344455 ERW13_RS10335 WP_001186602.1 2004364..2005992(+) (ccrB) [Staphylococcus aureus strain 592]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide

• Length: 1629 bp

>NTDB_id=344455 ERW13_RS10335 WP_001186602.1 2004364..2005992(+) (ccrB) [Staphylococcus aureus strain 592]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

• Ogr/Delta-like zinc finger (Ogr_Delta) (301-356)

• Resolvase, N terminal domain (Resolvase) (11-156)

• Recombinase (Recombinase) (180-280)

3D structure

• AlphaFold DB: Q9XB94

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	100	100	1