Detailed information NTG0341548

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: ETT62_RS06885
• Genome accession: NZ_CP035437
• Coordinates: 1368153..1369505 (-)
• Length: 450 a.a.
• NCBI ID: WP_030126091.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm78.3
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1363153..1374505

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT62_RS06875 (ETT62_06870)	rnc	1366205..1366897 (-)	693	WP_002990670.1	ribonuclease III	-
ETT62_RS06880 (ETT62_06875)	vicX	1367340..1368149 (-)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
ETT62_RS06885 (ETT62_06880)	vicK	1368153..1369505 (-)	1353	WP_030126091.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ETT62_RS06890 (ETT62_06885)	vicR	1369498..1370208 (-)	711	WP_002985645.1	response regulator YycF	Regulator
ETT62_RS06895 (ETT62_06890)	-	1370370..1371404 (-)	1035	WP_174147118.1	DUF3114 domain-containing protein	-
ETT62_RS06900 (ETT62_06895)	-	1371460..1372707 (-)	1248	WP_014407393.1	AMP-binding protein	-
ETT62_RS06905 (ETT62_06900)	-	1372664..1373812 (-)	1149	WP_030126093.1	acetyl-CoA C-acyltransferase	-
ETT62_RS06910 (ETT62_06905)	-	1374207..1374353 (-)	147	WP_030126094.1	hypothetical protein	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51449.86 Da
• Isoelectric Point: 5.2780

>NTDB_id=341548 ETT62_RS06885 WP_030126091.1 1368153..1369505(-) (vicK) [Streptococcus pyogenes strain emm78.3]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTDTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=341548 ETT62_RS06885 WP_030126091.1 1368153..1369505(-) (vicK) [Streptococcus pyogenes strain emm78.3]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGACTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGATACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATTC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• PAS fold (PAS) (95-162)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64