Detailed information NTG0341439

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: ETT64_RS05750
• Genome accession: NZ_CP035435
• Coordinates: 1091445..1092674 (-)
• Length: 409 a.a.
• NCBI ID: WP_002984948.1
• Uniprot ID: A0A4U7GJW1
• Organism: Streptococcus pyogenes strain emm64.3
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1086445..1097674

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT64_RS05730 (ETT64_05730)	rpiA	1086727..1087410 (-)	684	WP_009881270.1	ribose-5-phosphate isomerase RpiA	-
ETT64_RS05735 (ETT64_05735)	-	1087788..1089887 (+)	2100	WP_136292942.1	AAA family ATPase	-
ETT64_RS05740 (ETT64_05740)	-	1089945..1090688 (-)	744	WP_002984942.1	hypothetical protein	-
ETT64_RS05745 (ETT64_05745)	yihA	1090836..1091435 (-)	600	WP_038432912.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
ETT64_RS05750 (ETT64_05750)	clpX	1091445..1092674 (-)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
ETT64_RS05760 (ETT64_05760)	-	1092994..1093491 (-)	498	WP_002984955.1	dihydrofolate reductase	-
ETT64_RS05765 (ETT64_05765)	-	1093571..1094410 (-)	840	WP_011017679.1	thymidylate synthase	-
ETT64_RS05770 (ETT64_05770)	-	1094619..1095794 (+)	1176	WP_023609855.1	hydroxymethylglutaryl-CoA synthase	-
ETT64_RS05775 (ETT64_05775)	-	1095781..1097058 (+)	1278	WP_020833420.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 44991.44 Da
• Isoelectric Point: 4.5775

>NTDB_id=341439 ETT64_RS05750 WP_002984948.1 1091445..1092674(-) (clpX) [Streptococcus pyogenes strain emm64.3]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=341439 ETT64_RS05750 WP_002984948.1 1091445..1092674(-) (clpX) [Streptococcus pyogenes strain emm64.3]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTTCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATCGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAAACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CGATGTTAGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

3D structure

• AlphaFold DB: A0A4U7GJW1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.603	98.044	0.575