Detailed information    

insolico Bioinformatically predicted

Overview

Name   eeP   Type   Regulator
Locus tag   ETT65_RS08575 Genome accession   NZ_CP035434
Coordinates   1679676..1680935 (-) Length   419 a.a.
NCBI ID   WP_111694986.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm75.1     
Function   processing of ComS (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1625135..1694279 1679676..1680935 within 0


Gene organization within MGE regions


Location: 1625135..1694279
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT65_RS08280 (ETT65_08270) - 1625157..1625930 (+) 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
  ETT65_RS08290 (ETT65_08280) - 1626591..1626878 (+) 288 WP_002988079.1 DNA-damage-inducible protein J -
  ETT65_RS08295 (ETT65_08285) - 1626868..1627203 (+) 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ETT65_RS09740 - 1627301..1628307 (+) 1007 Protein_1545 tyrosine-type recombinase/integrase -
  ETT65_RS09745 - 1628627..1628713 (-) 87 WP_227874724.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ETT65_RS08310 (ETT65_08300) - 1628713..1628937 (-) 225 WP_227874722.1 hypothetical protein -
  ETT65_RS08315 (ETT65_08305) - 1629312..1632206 (+) 2895 WP_136096249.1 DNA methyltransferase -
  ETT65_RS08320 (ETT65_08310) - 1632221..1634605 (-) 2385 WP_115230700.1 restriction endonuclease -
  ETT65_RS08325 (ETT65_08315) - 1634589..1635053 (-) 465 WP_227874723.1 hypothetical protein -
  ETT65_RS08330 (ETT65_08320) - 1635280..1635957 (-) 678 Protein_1551 helix-turn-helix domain-containing protein -
  ETT65_RS08335 (ETT65_08325) - 1635960..1636823 (-) 864 WP_136076062.1 ImmA/IrrE family metallo-endopeptidase -
  ETT65_RS08345 (ETT65_08335) - 1637051..1638184 (-) 1134 WP_136119729.1 ISAs1-like element IS1548 family transposase -
  ETT65_RS08350 (ETT65_08340) - 1638637..1638885 (+) 249 WP_085634384.1 hypothetical protein -
  ETT65_RS08355 (ETT65_08345) - 1638923..1639219 (+) 297 WP_085634385.1 cytoplasmic protein -
  ETT65_RS08360 (ETT65_08350) - 1639238..1639693 (+) 456 WP_065736536.1 conjugal transfer protein -
  ETT65_RS08365 (ETT65_08355) - 1639709..1641388 (+) 1680 WP_136075998.1 FtsK/SpoIIIE domain-containing protein -
  ETT65_RS08370 (ETT65_08360) - 1641609..1642862 (+) 1254 WP_115230706.1 replication initiation factor domain-containing protein -
  ETT65_RS08375 (ETT65_08365) - 1642919..1643200 (+) 282 WP_017649870.1 hypothetical protein -
  ETT65_RS08380 (ETT65_08370) - 1643193..1643528 (+) 336 WP_227874721.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ETT65_RS08385 (ETT65_08375) - 1643592..1643822 (+) 231 WP_085634389.1 hypothetical protein -
  ETT65_RS08390 (ETT65_08380) - 1643843..1644394 (+) 552 WP_115230708.1 conjugal transfer protein -
  ETT65_RS08395 (ETT65_08385) - 1644407..1645387 (+) 981 WP_136097914.1 conjugal transfer protein -
  ETT65_RS08400 (ETT65_08390) - 1645393..1645617 (+) 225 WP_115230710.1 hypothetical protein -
  ETT65_RS08405 (ETT65_08395) - 1645619..1646041 (+) 423 WP_085634393.1 conjugal transfer protein -
  ETT65_RS08410 (ETT65_08400) - 1646054..1648558 (+) 2505 Protein_1566 ATP-binding protein -
  ETT65_RS08415 (ETT65_08405) - 1648573..1650483 (+) 1911 WP_136096193.1 conjugal transfer protein -
  ETT65_RS08420 (ETT65_08410) - 1650470..1650697 (+) 228 WP_115230712.1 hypothetical protein -
  ETT65_RS08425 (ETT65_08415) - 1650716..1651828 (+) 1113 WP_136076001.1 phage tail tip lysozyme -
  ETT65_RS08430 (ETT65_08420) - 1652012..1652257 (+) 246 WP_115230714.1 helix-turn-helix domain-containing protein -
  ETT65_RS08435 (ETT65_08425) - 1652297..1653510 (+) 1214 Protein_1571 tyrosine-type recombinase/integrase -
  ETT65_RS08440 (ETT65_08430) rpsI 1653620..1654012 (-) 393 WP_002982716.1 30S ribosomal protein S9 -
  ETT65_RS08445 (ETT65_08435) rplM 1654033..1654479 (-) 447 WP_136038114.1 50S ribosomal protein L13 -
  ETT65_RS08450 (ETT65_08440) - 1654697..1654903 (-) 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
  ETT65_RS08455 (ETT65_08445) - 1654900..1655598 (-) 699 WP_168410082.1 hypothetical protein -
  ETT65_RS08460 (ETT65_08450) - 1655734..1656594 (-) 861 WP_011529009.1 DegV family protein -
  ETT65_RS08465 (ETT65_08455) - 1656691..1657209 (-) 519 WP_002982682.1 NYN domain-containing protein -
  ETT65_RS08470 (ETT65_08460) rlmB 1657213..1657959 (-) 747 WP_009880997.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
  ETT65_RS08475 (ETT65_08465) - 1658006..1658803 (-) 798 WP_047235493.1 hypothetical protein -
  ETT65_RS08480 (ETT65_08470) - 1658999..1659412 (-) 414 WP_002982672.1 Mini-ribonuclease 3 -
  ETT65_RS08485 (ETT65_08475) cysS 1659405..1660748 (-) 1344 WP_136038113.1 cysteine--tRNA ligase -
  ETT65_RS08490 (ETT65_08480) - 1660776..1661006 (-) 231 WP_136037690.1 hypothetical protein -
  ETT65_RS08500 (ETT65_08490) cysE 1661485..1662066 (-) 582 WP_002982658.1 serine O-acetyltransferase -
  ETT65_RS08505 (ETT65_08495) - 1662075..1662827 (-) 753 WP_002988058.1 SseB family protein -
  ETT65_RS08510 (ETT65_08500) pnp 1662820..1664952 (-) 2133 WP_011285185.1 polyribonucleotide nucleotidyltransferase -
  ETT65_RS08515 (ETT65_08505) - 1665232..1665963 (-) 732 WP_136076002.1 transaldolase -
  ETT65_RS08520 (ETT65_08510) - 1665973..1667352 (-) 1380 WP_002994557.1 PTS ascorbate transporter subunit IIC -
  ETT65_RS08525 (ETT65_08515) - 1667379..1667663 (-) 285 WP_002982644.1 PTS sugar transporter subunit IIB -
  ETT65_RS08530 (ETT65_08520) - 1667656..1669716 (-) 2061 WP_136076003.1 BglG family transcription antiterminator -
  ETT65_RS08535 (ETT65_08525) rpsO 1670068..1670337 (-) 270 WP_002982634.1 30S ribosomal protein S15 -
  ETT65_RS08540 (ETT65_08530) - 1670513..1670713 (-) 201 WP_002982630.1 hypothetical protein -
  ETT65_RS08545 (ETT65_08535) - 1670839..1671009 (+) 171 Protein_1592 transcriptional regulator -
  ETT65_RS08550 (ETT65_08540) def 1671112..1671726 (+) 615 WP_011018241.1 peptide deformylase -
  ETT65_RS08555 (ETT65_08545) - 1671760..1672302 (-) 543 WP_023610181.1 NADPH-dependent FMN reductase -
  ETT65_RS08560 (ETT65_08550) - 1672433..1672861 (-) 429 WP_002982615.1 MarR family winged helix-turn-helix transcriptional regulator -
  ETT65_RS08565 (ETT65_08555) - 1672971..1677368 (-) 4398 WP_136076005.1 PolC-type DNA polymerase III -
  ETT65_RS08570 (ETT65_08560) - 1677622..1679478 (-) 1857 WP_014407862.1 proline--tRNA ligase -
  ETT65_RS08575 (ETT65_08565) eeP 1679676..1680935 (-) 1260 WP_111694986.1 RIP metalloprotease RseP Regulator
  ETT65_RS08580 (ETT65_08570) - 1681008..1681802 (-) 795 WP_136038108.1 phosphatidate cytidylyltransferase -
  ETT65_RS08585 (ETT65_08575) - 1681815..1682564 (-) 750 WP_110002877.1 isoprenyl transferase -
  ETT65_RS08590 (ETT65_08580) yajC 1682783..1683148 (-) 366 WP_002988027.1 preprotein translocase subunit YajC -
  ETT65_RS08595 (ETT65_08585) - 1683264..1683638 (-) 375 WP_011184989.1 thioredoxin domain-containing protein -
  ETT65_RS08600 (ETT65_08590) - 1683754..1687251 (-) 3498 WP_136128045.1 pullulanase -
  ETT65_RS08610 (ETT65_08600) dexB 1687449..1689062 (-) 1614 WP_136128043.1 glucan 1,6-alpha-glucosidase DexB -
  ETT65_RS08615 (ETT65_08605) - 1689191..1690324 (-) 1134 WP_002993686.1 ABC transporter ATP-binding protein -
  ETT65_RS08620 (ETT65_08610) - 1690622..1691470 (-) 849 WP_136128048.1 helix-turn-helix domain-containing protein -
  ETT65_RS08625 (ETT65_08615) ska 1691810..1693132 (+) 1323 WP_136128042.1 streptokinase -
  ETT65_RS08630 (ETT65_08620) dtd 1693230..1693673 (-) 444 WP_009881013.1 D-aminoacyl-tRNA deacylase -

Sequence

Protein


Download         Length: 419 a.a.        Molecular weight: 45739.45 Da        Isoelectric Point: 9.2387

>NTDB_id=341397 ETT65_RS08575 WP_111694986.1 1679676..1680935(-) (eeP) [Streptococcus pyogenes strain emm75.1]
MLGIITFIIIFGILVIVHEFGHFYFAKKSGILVREFAIGMGPKIFSHVDQGGTLYTLRMLPLGGYVRMAGWGDDKTEIKT
GTPASLTLNEQGFVKRINLSQSKLDPTSLPMHVTGYDLEDQLSITGLVLEETKTYKVAHDATIVEEDGTEIRIAPLDVQY
QNASIGGRLITNFAGPMNNFILGIVVFILLVFLQGGMSDFSSNHVRVQENGAAAKAGLRDNDQIVAINGYKVTSWNDLTE
AVDLATRDLGPSQTIKVTYKSHQRLKTVAVKPQKHAKTYTIGVKASLKTGFKDKLLGGLELAWSGAFTILNTLKGLITGF
SLNKLGGPVAMYDMSNQAAQNGLESVLSLMAMLSINLGIFNLIPIPALDGGKILMNIIEAIRRKPIKQETEAYITLAGVA
IMVVLMIAVTWNDIMRVFF

Nucleotide


Download         Length: 1260 bp        

>NTDB_id=341397 ETT65_RS08575 WP_111694986.1 1679676..1680935(-) (eeP) [Streptococcus pyogenes strain emm75.1]
ATGTTAGGAATAATAACCTTTATTATTATTTTTGGTATTTTAGTGATTGTCCATGAATTTGGACATTTCTATTTTGCTAA
AAAATCAGGCATTCTAGTAAGAGAATTTGCCATTGGAATGGGCCCTAAAATTTTTTCTCATGTTGACCAAGGAGGAACTC
TTTATACCTTGAGGATGTTACCCTTGGGTGGTTATGTGCGAATGGCTGGTTGGGGTGATGACAAAACTGAGATCAAAACA
GGTACTCCAGCAAGTTTAACCCTTAATGAGCAAGGTTTTGTTAAGCGCATCAACTTGTCTCAAAGTAAGTTAGACCCAAC
GAGTCTCCCAATGCATGTTACAGGCTATGACTTAGAAGATCAGCTGAGTATTACTGGCTTGGTTTTAGAAGAAACCAAGA
CATATAAGGTCGCTCACGATGCTACTATTGTTGAAGAAGACGGTACTGAGATAAGAATTGCTCCGCTTGATGTTCAATAT
CAAAATGCTAGTATTGGCGGACGTTTAATCACCAATTTTGCAGGTCCCATGAATAATTTTATTTTAGGAATTGTGGTTTT
TATCCTCTTGGTCTTTTTACAAGGTGGGATGTCAGATTTTAGTAGCAATCATGTCCGTGTTCAAGAAAATGGAGCAGCAG
CTAAGGCTGGTCTTCGAGATAATGACCAAATTGTCGCAATTAATGGTTATAAGGTGACTAGCTGGAATGATCTTACTGAG
GCTGTAGACCTTGCAACACGGGATCTAGGCCCGTCACAGACCATTAAGGTCACCTACAAGTCACATCAGCGCTTAAAAAC
GGTGGCTGTGAAACCACAAAAGCATGCAAAGACATACACGATAGGAGTTAAGGCGAGTCTGAAAACAGGATTTAAGGATA
AGCTCTTAGGCGGTCTAGAATTAGCTTGGAGTGGGGCGTTTACTATTTTGAATACTTTGAAAGGATTGATCACTGGCTTT
AGTCTCAATAAATTAGGTGGACCTGTTGCCATGTATGACATGTCCAATCAGGCTGCTCAAAACGGCTTAGAGTCAGTCTT
ATCTCTTATGGCAATGCTTTCGATCAATTTAGGGATCTTTAACCTGATTCCGATTCCTGCACTTGATGGGGGAAAAATCT
TGATGAATATCATTGAAGCCATCCGTCGCAAGCCTATCAAGCAAGAAACAGAGGCCTATATCACCCTAGCTGGGGTTGCT
ATCATGGTCGTATTGATGATTGCTGTGACATGGAATGATATCATGCGCGTCTTTTTCTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(206-271)

Peptidase family M50 (Peptidase_M50)

(6-405)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  eeP Streptococcus thermophilus LMG 18311

68.81

100

0.69
  eeP Streptococcus thermophilus LMD-9

68.571

100

0.687

Multiple sequence alignment