Detailed information NTG0341218

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: ETT68_RS02355
• Genome accession: NZ_CP035431
• Coordinates: 430881..432233 (+)
• Length: 450 a.a.
• NCBI ID: WP_111676637.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm105
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 425881..437233

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT68_RS02330 (ETT68_02325)	-	426030..426179 (+)	150	WP_002990686.1	hypothetical protein	-
ETT68_RS02335 (ETT68_02330)	-	426574..427722 (+)	1149	WP_109991792.1	acetyl-CoA C-acyltransferase	-
ETT68_RS02340 (ETT68_02335)	-	427679..428926 (+)	1248	WP_109991791.1	AMP-binding protein	-
ETT68_RS02345 (ETT68_02340)	-	428982..430016 (+)	1035	WP_186788706.1	DUF3114 domain-containing protein	-
ETT68_RS02350 (ETT68_02345)	vicR	430178..430888 (+)	711	WP_002985645.1	response regulator YycF	Regulator
ETT68_RS02355 (ETT68_02350)	vicK	430881..432233 (+)	1353	WP_111676637.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ETT68_RS02360 (ETT68_02355)	vicX	432237..433046 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
ETT68_RS02365 (ETT68_02360)	rnc	433489..434181 (+)	693	WP_002990670.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51433.90 Da
• Isoelectric Point: 5.4026

>NTDB_id=341218 ETT68_RS02355 WP_111676637.1 430881..432233(+) (vicK) [Streptococcus pyogenes strain emm105]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTVTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=341218 ETT68_RS02355 WP_111676637.1 430881..432233(+) (vicK) [Streptococcus pyogenes strain emm105]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGACTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGATGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGTTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGTTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64