Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   F4V40_RS12765 Genome accession   NZ_CP044145
Coordinates   2365190..2365846 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O157 strain AR-0428     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2360190..2370846
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  F4V40_RS12725 - 2360193..2361326 (-) 1134 WP_032161728.1 IS30-like element IS30 family transposase -
  F4V40_RS12730 - 2361268..2361462 (-) 195 WP_115801851.1 hypothetical protein -
  F4V40_RS12735 - 2361483..2361764 (-) 282 WP_001303543.1 hypothetical protein -
  F4V40_RS12755 pgsA 2362756..2363304 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  F4V40_RS12760 uvrC 2363361..2365193 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  F4V40_RS12765 letA 2365190..2365846 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  F4V40_RS30260 - 2365988..2366104 (+) 117 WP_001302039.1 hypothetical protein -
  F4V40_RS12775 yecU 2366142..2366318 (+) 177 WP_001302050.1 protein YecU -
  F4V40_RS12780 yecF 2366305..2366529 (+) 225 WP_000106479.1 DUF2594 family protein YecF -
  F4V40_RS12785 sdiA 2366597..2367319 (-) 723 WP_001154288.1 transcriptional regulator SdiA -
  F4V40_RS12790 tcyN 2367549..2368301 (-) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  F4V40_RS12795 tcyL 2368298..2368966 (-) 669 WP_001158226.1 cystine ABC transporter permease -
  F4V40_RS12800 dcyD 2368981..2369967 (-) 987 WP_001128225.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=341055 F4V40_RS12765 WP_000611328.1 2365190..2365846(-) (letA) [Escherichia coli O157 strain AR-0428]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=341055 F4V40_RS12765 WP_000611328.1 2365190..2365846(-) (letA) [Escherichia coli O157 strain AR-0428]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482

Multiple sequence alignment