Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | ESP48_RS03300 | Genome accession | NZ_CP035306 |
| Coordinates | 621570..622646 (-) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain IDCC2201 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 606825..679625 | 621570..622646 | within | 0 |
Gene organization within MGE regions
Location: 606825..679625
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ESP48_RS03230 (ESP48_03230) | - | 607716..608267 (-) | 552 | WP_002946999.1 | cysteine hydrolase family protein | - |
| ESP48_RS03235 (ESP48_03235) | codY | 608330..609115 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| ESP48_RS03240 (ESP48_03240) | - | 609375..610589 (-) | 1215 | WP_002951721.1 | pyridoxal phosphate-dependent aminotransferase | - |
| ESP48_RS03245 (ESP48_03245) | - | 610944..611396 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| ESP48_RS10055 (ESP48_03250) | - | 611576..612147 (+) | 572 | Protein_620 | IS30 family transposase | - |
| ESP48_RS09670 | - | 612219..612392 (-) | 174 | WP_014621904.1 | hypothetical protein | - |
| ESP48_RS03255 (ESP48_03255) | - | 612453..612827 (-) | 375 | WP_011681547.1 | membrane protein | - |
| ESP48_RS03260 (ESP48_03260) | pflA | 613039..613839 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| ESP48_RS09675 | - | 614027..614137 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| ESP48_RS03270 (ESP48_03270) | - | 614835..616166 (-) | 1332 | WP_002951727.1 | hemolysin family protein | - |
| ESP48_RS03275 (ESP48_03275) | - | 616278..617060 (+) | 783 | WP_011226459.1 | ABC transporter ATP-binding protein | - |
| ESP48_RS03280 (ESP48_03280) | - | 617682..619748 (-) | 2067 | WP_064355828.1 | cation:proton antiporter | - |
| ESP48_RS03285 (ESP48_03285) | - | 619757..619999 (-) | 243 | WP_011226461.1 | hypothetical protein | - |
| ESP48_RS03290 (ESP48_03290) | - | 619996..620544 (-) | 549 | WP_011226462.1 | tRNA (mnm(5)s(2)U34)-methyltransferase | - |
| ESP48_RS03295 (ESP48_03295) | - | 620541..621485 (-) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| ESP48_RS03300 (ESP48_03300) | sepM | 621570..622646 (-) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| ESP48_RS03305 (ESP48_03305) | coaD | 622624..623121 (-) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| ESP48_RS03310 (ESP48_03310) | rsmD | 623155..623694 (-) | 540 | WP_002951741.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| ESP48_RS03315 (ESP48_03315) | trxB | 623845..624765 (-) | 921 | WP_011226467.1 | thioredoxin-disulfide reductase | - |
| ESP48_RS03320 (ESP48_03320) | - | 624831..625055 (-) | 225 | WP_002951743.1 | DUF4059 family protein | - |
| ESP48_RS03325 (ESP48_03325) | - | 625270..626013 (-) | 744 | WP_011681551.1 | amino acid ABC transporter ATP-binding protein | - |
| ESP48_RS03330 (ESP48_03330) | - | 626013..626759 (-) | 747 | WP_095559509.1 | amino acid ABC transporter permease | - |
| ESP48_RS03335 (ESP48_03335) | - | 627147..627977 (-) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| ESP48_RS03340 (ESP48_03340) | - | 628437..628670 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| ESP48_RS03345 (ESP48_03345) | dinB | 628968..630071 (-) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| ESP48_RS03350 (ESP48_03350) | pflB | 630350..632659 (+) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| ESP48_RS03355 (ESP48_03355) | - | 632926..633708 (+) | 783 | WP_011681555.1 | carbonic anhydrase | - |
| ESP48_RS03360 (ESP48_03360) | - | 633759..634211 (+) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| ESP48_RS03370 (ESP48_03370) | - | 634562..634846 (-) | 285 | WP_014608656.1 | restriction endonuclease subunit S | - |
| ESP48_RS10480 (ESP48_03375) | mobV | 634892..635400 (-) | 509 | Protein_645 | MobV family relaxase | - |
| ESP48_RS03380 (ESP48_03380) | - | 635845..636600 (-) | 756 | WP_011681558.1 | ABC transporter permease | - |
| ESP48_RS03385 (ESP48_03385) | - | 636597..637247 (-) | 651 | WP_024703990.1 | ABC transporter ATP-binding protein | - |
| ESP48_RS03390 (ESP48_03390) | - | 637450..638406 (-) | 957 | WP_024703991.1 | serine hydrolase domain-containing protein | - |
| ESP48_RS03395 (ESP48_03395) | - | 638406..639161 (-) | 756 | WP_064355831.1 | CppA family protein | - |
| ESP48_RS03400 (ESP48_03400) | - | 639443..639805 (+) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| ESP48_RS03405 (ESP48_03405) | gla | 639892..640755 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| ESP48_RS03410 (ESP48_03410) | - | 640876..643143 (+) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| ESP48_RS03415 (ESP48_03415) | - | 643223..643603 (-) | 381 | WP_064355833.1 | hypothetical protein | - |
| ESP48_RS03420 (ESP48_03420) | - | 643728..643991 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| ESP48_RS03425 (ESP48_03425) | - | 644313..644609 (-) | 297 | WP_064355835.1 | bacteriocin immunity protein | - |
| ESP48_RS10610 (ESP48_03430) | - | 644774..644980 (-) | 207 | WP_011681562.1 | hypothetical protein | - |
| ESP48_RS03435 (ESP48_03435) | - | 645011..645658 (-) | 648 | WP_231079884.1 | thioredoxin family protein | - |
| ESP48_RS03440 (ESP48_03440) | - | 645893..647463 (+) | 1571 | WP_128887979.1 | IS3-like element ISSth1b family transposase | - |
| ESP48_RS03445 (ESP48_03445) | - | 647609..647863 (-) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| ESP48_RS10485 (ESP48_03450) | - | 648114..648515 (-) | 402 | WP_024703992.1 | hypothetical protein | - |
| ESP48_RS03460 (ESP48_03460) | - | 649520..649750 (-) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| ESP48_RS03465 (ESP48_03465) | - | 650106..650306 (-) | 201 | WP_011681569.1 | hypothetical protein | - |
| ESP48_RS03470 (ESP48_03470) | - | 650325..650501 (-) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| ESP48_RS03475 (ESP48_03475) | - | 650757..651494 (+) | 738 | WP_064356014.1 | LytR/AlgR family response regulator transcription factor | - |
| ESP48_RS10065 | - | 652025..652828 (+) | 804 | WP_223899638.1 | ATP-binding protein | - |
| ESP48_RS03485 (ESP48_03485) | - | 652846..653007 (-) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| ESP48_RS03490 (ESP48_03490) | - | 653022..654389 (-) | 1368 | WP_064356015.1 | bacteriocin secretion accessory protein | - |
| ESP48_RS03495 (ESP48_03495) | comA/nlmT | 654405..656558 (-) | 2154 | WP_041827378.1 | peptide cleavage/export ABC transporter | Regulator |
| ESP48_RS03510 (ESP48_03510) | - | 657572..659317 (-) | 1746 | WP_014621922.1 | ABC transporter ATP-binding protein | - |
| ESP48_RS03515 (ESP48_03515) | - | 659310..661067 (-) | 1758 | WP_014608668.1 | ABC transporter ATP-binding protein | - |
| ESP48_RS10070 (ESP48_03520) | - | 661255..661461 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| ESP48_RS03525 (ESP48_03525) | - | 661666..662193 (-) | 528 | WP_011226503.1 | VanZ family protein | - |
| ESP48_RS03530 (ESP48_03530) | rlmN | 662195..663364 (-) | 1170 | WP_064356075.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| ESP48_RS03535 (ESP48_03535) | - | 663368..664090 (-) | 723 | WP_011226505.1 | YutD family protein | - |
| ESP48_RS03540 (ESP48_03540) | - | 664145..665500 (-) | 1356 | WP_041827845.1 | bifunctional metallophosphatase/5'-nucleotidase | - |
| ESP48_RS10410 | - | 665779..665910 (-) | 132 | WP_258380174.1 | hypothetical protein | - |
| ESP48_RS03545 (ESP48_03545) | - | 666349..667692 (-) | 1344 | WP_011681583.1 | DEAD/DEAH box helicase | - |
| ESP48_RS03550 (ESP48_03550) | mraY | 667767..668789 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| ESP48_RS03555 (ESP48_03555) | pbp2X | 668791..671058 (-) | 2268 | WP_064356077.1 | penicillin-binding protein PBP2X | - |
| ESP48_RS03560 (ESP48_03560) | ftsL | 671062..671382 (-) | 321 | WP_014608671.1 | cell division protein FtsL | - |
| ESP48_RS03565 (ESP48_03565) | rsmH | 671385..672335 (-) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| ESP48_RS10075 (ESP48_03570) | - | 672502..672930 (-) | 429 | WP_064356079.1 | hypothetical protein | - |
| ESP48_RS10080 | - | 672896..673237 (-) | 342 | WP_231079881.1 | hypothetical protein | - |
| ESP48_RS10085 | - | 673715..673858 (-) | 144 | WP_014621937.1 | hypothetical protein | - |
| ESP48_RS03590 (ESP48_03590) | - | 674132..674488 (-) | 357 | WP_014621938.1 | DUF805 domain-containing protein | - |
| ESP48_RS03595 (ESP48_03595) | - | 674708..674998 (-) | 291 | WP_014621939.1 | hypothetical protein | - |
| ESP48_RS03600 (ESP48_03600) | - | 675332..676582 (-) | 1251 | WP_014621940.1 | glutamate-5-semialdehyde dehydrogenase | - |
| ESP48_RS03605 (ESP48_03605) | proB | 676584..677387 (-) | 804 | WP_014621941.1 | glutamate 5-kinase | - |
| ESP48_RS03610 (ESP48_03610) | - | 677508..679097 (-) | 1590 | WP_014608677.1 | ABC transporter permease | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=339165 ESP48_RS03300 WP_011681549.1 621570..622646(-) (sepM) [Streptococcus thermophilus strain IDCC2201]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=339165 ESP48_RS03300 WP_011681549.1 621570..622646(-) (sepM) [Streptococcus thermophilus strain IDCC2201]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |