Detailed information NTG0338718

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH15_RS09225
• Genome accession: NZ_CP035265
• Coordinates: 1795849..1796886 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_1901920
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1790849..1801886

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH15_RS09200 (EQH15_09680)	-	1791588..1792919 (-)	1332	WP_000390039.1	hemolysin family protein	-
EQH15_RS09205 (EQH15_09685)	endA	1793210..1794034 (-)	825	WP_001036786.1	DNA-entry nuclease EndA	Machinery gene
EQH15_RS09210 (EQH15_09690)	-	1794073..1794261 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
EQH15_RS09215 (EQH15_09695)	murA	1794254..1795537 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH15_RS09220 (EQH15_09700)	-	1795561..1795791 (-)	231	WP_000250393.1	DUF1146 family protein	-
EQH15_RS09225 (EQH15_09705)	sepM	1795849..1796886 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH15_RS09230 (EQH15_09710)	coaD	1796870..1797358 (-)	489	WP_001280727.1	pantetheine-phosphate adenylyltransferase	-
EQH15_RS09235 (EQH15_09715)	rsmD	1797348..1797887 (-)	540	WP_000706967.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH15_RS09240 (EQH15_09720)	asnA	1797952..1798944 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH15_RS09245 (EQH15_09730)	-	1799057..1799740 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQH15_RS09250 (EQH15_09735)	-	1799796..1800536 (-)	741	WP_001841916.1	RNA methyltransferase	-
EQH15_RS09255 (EQH15_09740)	-	1800570..1800848 (+)	279	WP_001174613.1	acylphosphatase	-
EQH15_RS09260 (EQH15_09745)	yidC	1800926..1801852 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=338718 EQH15_RS09225 WP_000727277.1 1795849..1796886(-) (sepM) [Streptococcus pneumoniae strain TVO_1901920]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=338718 EQH15_RS09225 WP_000727277.1 1795849..1796886(-) (sepM) [Streptococcus pneumoniae strain TVO_1901920]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCACAAAATATGGCCAAGTATCAAGGTCTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGGGTTTATGTCT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGAATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591