Detailed information NTG0338331

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH20_RS08655
• Genome accession: NZ_CP035260
• Coordinates: 1713935..1714972 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_1901925
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1708935..1719972

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH20_RS08630 (EQH20_09120)	-	1709674..1711005 (-)	1332	WP_000390042.1	hemolysin family protein	-
EQH20_RS08635 (EQH20_09125)	endA	1711296..1712120 (-)	825	WP_001036781.1	DNA-entry nuclease EndA	Machinery gene
EQH20_RS08640 (EQH20_09130)	-	1712159..1712347 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EQH20_RS08645 (EQH20_09135)	murA	1712340..1713623 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH20_RS08650 (EQH20_09140)	-	1713647..1713877 (-)	231	WP_000250384.1	DUF1146 family protein	-
EQH20_RS08655 (EQH20_09145)	sepM	1713935..1714972 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH20_RS08660 (EQH20_09150)	coaD	1714956..1715444 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
EQH20_RS08665 (EQH20_09155)	rsmD	1715434..1715973 (-)	540	WP_001819515.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH20_RS08670 (EQH20_09160)	asnA	1716038..1717030 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH20_RS08675 (EQH20_09170)	-	1717142..1717825 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQH20_RS08680 (EQH20_09175)	-	1717881..1718621 (-)	741	WP_000152678.1	RNA methyltransferase	-
EQH20_RS08685 (EQH20_09180)	-	1718655..1718933 (+)	279	WP_001174613.1	acylphosphatase	-
EQH20_RS08690 (EQH20_09185)	yidC	1719011..1719937 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=338331 EQH20_RS08655 WP_000727277.1 1713935..1714972(-) (sepM) [Streptococcus pneumoniae strain TVO_1901925]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=338331 EQH20_RS08655 WP_000727277.1 1713935..1714972(-) (sepM) [Streptococcus pneumoniae strain TVO_1901925]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591