Detailed information
Bioinformatically predicted
Overview
| Name | clpX | Type | Regulator |
| Locus tag | EQH28_RS07355 | Genome accession | NZ_CP035252 |
| Coordinates | 1460020..1461252 (-) | Length | 410 a.a. |
| NCBI ID | WP_000106346.1 | Uniprot ID | A0A064C077 |
| Organism | Streptococcus pneumoniae strain TVO_1901934 | ||
| Function | require for competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1415464..1470313 | 1460020..1461252 | within | 0 |
Gene organization within MGE regions
Location: 1415464..1470313
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EQH28_RS07030 (EQH28_07475) | lytA | 1415464..1416420 (-) | 957 | WP_000350486.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| EQH28_RS07035 (EQH28_07480) | - | 1416424..1416756 (-) | 333 | WP_001186242.1 | phage holin | - |
| EQH28_RS07040 (EQH28_07485) | - | 1416760..1417176 (-) | 417 | WP_057519042.1 | phage holin family protein | - |
| EQH28_RS07045 (EQH28_07490) | - | 1417186..1417536 (-) | 351 | WP_000852249.1 | hypothetical protein | - |
| EQH28_RS07050 (EQH28_07495) | - | 1417539..1417742 (-) | 204 | WP_044793701.1 | hypothetical protein | - |
| EQH28_RS07055 | - | 1417723..1417839 (-) | 117 | WP_001063633.1 | hypothetical protein | - |
| EQH28_RS07060 | - | 1417836..1423442 (-) | 5607 | WP_238122307.1 | tail fiber domain-containing protein | - |
| EQH28_RS07065 (EQH28_07515) | - | 1423447..1423797 (-) | 351 | WP_000068026.1 | DUF6711 family protein | - |
| EQH28_RS07070 (EQH28_07520) | - | 1423806..1427459 (-) | 3654 | WP_088834556.1 | hypothetical protein | - |
| EQH28_RS07075 (EQH28_07525) | - | 1427446..1427796 (-) | 351 | WP_000478010.1 | hypothetical protein | - |
| EQH28_RS07080 (EQH28_07530) | - | 1427835..1428215 (-) | 381 | WP_001185635.1 | DUF6096 family protein | - |
| EQH28_RS07085 (EQH28_07535) | - | 1428220..1428633 (-) | 414 | WP_000880678.1 | phage tail tube protein | - |
| EQH28_RS07090 (EQH28_07540) | - | 1428636..1429004 (-) | 369 | WP_000608233.1 | hypothetical protein | - |
| EQH28_RS07095 (EQH28_07545) | - | 1429001..1429516 (-) | 516 | WP_000015941.1 | HK97-gp10 family putative phage morphogenesis protein | - |
| EQH28_RS07100 (EQH28_07550) | - | 1429491..1429829 (-) | 339 | WP_000478943.1 | hypothetical protein | - |
| EQH28_RS07105 (EQH28_07555) | - | 1429810..1430121 (-) | 312 | WP_000021219.1 | phage head-tail connector protein | - |
| EQH28_RS07110 (EQH28_07560) | - | 1430123..1430311 (-) | 189 | WP_000669349.1 | hypothetical protein | - |
| EQH28_RS07115 (EQH28_07565) | - | 1430301..1430483 (-) | 183 | WP_000054934.1 | Rho termination factor N-terminal domain-containing protein | - |
| EQH28_RS07120 (EQH28_07570) | - | 1430495..1431340 (-) | 846 | WP_000123890.1 | N4-gp56 family major capsid protein | - |
| EQH28_RS07125 (EQH28_07575) | - | 1431347..1431931 (-) | 585 | WP_001288024.1 | DUF4355 domain-containing protein | - |
| EQH28_RS07130 (EQH28_07580) | - | 1432101..1432313 (-) | 213 | WP_000393349.1 | crAss001_48 related protein | - |
| EQH28_RS07135 | - | 1432458..1432631 (-) | 174 | WP_000379086.1 | hypothetical protein | - |
| EQH28_RS07140 (EQH28_07585) | - | 1432782..1434332 (-) | 1551 | WP_179127978.1 | minor capsid protein | - |
| EQH28_RS07145 (EQH28_07590) | - | 1434241..1435710 (-) | 1470 | WP_088834552.1 | phage portal protein | - |
| EQH28_RS07150 (EQH28_07595) | - | 1435722..1437020 (-) | 1299 | WP_238122309.1 | PBSX family phage terminase large subunit | - |
| EQH28_RS07155 (EQH28_07600) | - | 1436998..1437438 (-) | 441 | WP_014931818.1 | terminase small subunit | - |
| EQH28_RS07165 (EQH28_07605) | - | 1437912..1438334 (-) | 423 | WP_001030244.1 | DUF1492 domain-containing protein | - |
| EQH28_RS07170 (EQH28_07610) | - | 1438404..1438775 (-) | 372 | WP_001247151.1 | hypothetical protein | - |
| EQH28_RS07175 (EQH28_07615) | - | 1438772..1439209 (-) | 438 | WP_000612395.1 | YopX family protein | - |
| EQH28_RS07180 (EQH28_07625) | - | 1439322..1439780 (-) | 459 | WP_000340952.1 | hypothetical protein | - |
| EQH28_RS07185 (EQH28_07630) | - | 1439780..1440040 (-) | 261 | WP_000819330.1 | DUF1372 family protein | - |
| EQH28_RS11230 | - | 1440037..1440159 (-) | 123 | WP_001842508.1 | hypothetical protein | - |
| EQH28_RS07190 (EQH28_07635) | - | 1440198..1440893 (-) | 696 | WP_061364775.1 | DUF1642 domain-containing protein | - |
| EQH28_RS07195 | - | 1440890..1441045 (-) | 156 | WP_000122744.1 | hypothetical protein | - |
| EQH28_RS07200 (EQH28_07640) | - | 1441345..1442682 (-) | 1338 | WP_016397659.1 | virulence-associated E family protein | - |
| EQH28_RS07205 (EQH28_07645) | - | 1442685..1443506 (-) | 822 | WP_001139684.1 | bifunctional DNA primase/polymerase | - |
| EQH28_RS07210 (EQH28_07650) | - | 1443679..1444182 (-) | 504 | WP_000054339.1 | hypothetical protein | - |
| EQH28_RS07215 (EQH28_07655) | - | 1444202..1445029 (-) | 828 | WP_000885997.1 | AAA family ATPase | - |
| EQH28_RS07220 (EQH28_07660) | - | 1445029..1445346 (-) | 318 | WP_001044592.1 | hypothetical protein | - |
| EQH28_RS07225 (EQH28_07665) | - | 1445365..1446558 (-) | 1194 | WP_000028858.1 | DEAD/DEAH box helicase family protein | - |
| EQH28_RS07230 (EQH28_07670) | - | 1446521..1447006 (-) | 486 | WP_238122311.1 | hypothetical protein | - |
| EQH28_RS07235 (EQH28_07675) | - | 1447006..1447356 (-) | 351 | WP_224757118.1 | hypothetical protein | - |
| EQH28_RS07240 (EQH28_07680) | - | 1447365..1447847 (-) | 483 | WP_000157806.1 | siphovirus Gp157 family protein | - |
| EQH28_RS07245 (EQH28_07685) | - | 1447840..1448562 (-) | 723 | WP_000544341.1 | HNH endonuclease signature motif containing protein | - |
| EQH28_RS07250 (EQH28_07690) | - | 1448576..1448806 (-) | 231 | WP_000252078.1 | hypothetical protein | - |
| EQH28_RS07255 (EQH28_07695) | - | 1448807..1449148 (-) | 342 | WP_000189406.1 | hypothetical protein | - |
| EQH28_RS07260 (EQH28_07700) | - | 1449160..1449348 (-) | 189 | WP_000455779.1 | hypothetical protein | - |
| EQH28_RS07265 (EQH28_07705) | - | 1449327..1449542 (-) | 216 | WP_001050925.1 | hypothetical protein | - |
| EQH28_RS07270 (EQH28_07710) | - | 1449539..1449811 (-) | 273 | WP_000388508.1 | hypothetical protein | - |
| EQH28_RS07275 (EQH28_07715) | - | 1449929..1450168 (+) | 240 | WP_000134993.1 | hypothetical protein | - |
| EQH28_RS07280 | - | 1450161..1450331 (-) | 171 | WP_000656631.1 | hypothetical protein | - |
| EQH28_RS07285 | - | 1450328..1450471 (-) | 144 | WP_000389590.1 | hypothetical protein | - |
| EQH28_RS07290 (EQH28_07720) | - | 1450590..1450781 (+) | 192 | WP_000834563.1 | hypothetical protein | - |
| EQH28_RS07295 | - | 1451180..1451380 (-) | 201 | WP_000446708.1 | hypothetical protein | - |
| EQH28_RS07300 (EQH28_07730) | - | 1451412..1451627 (-) | 216 | WP_001198773.1 | helix-turn-helix transcriptional regulator | - |
| EQH28_RS07305 | - | 1451646..1451810 (-) | 165 | WP_000662050.1 | hypothetical protein | - |
| EQH28_RS11235 | - | 1451826..1451960 (-) | 135 | WP_001247818.1 | hypothetical protein | - |
| EQH28_RS07310 (EQH28_07735) | - | 1452017..1452706 (+) | 690 | WP_000577515.1 | DUF4145 domain-containing protein | - |
| EQH28_RS07315 (EQH28_07740) | - | 1452950..1453741 (+) | 792 | WP_000343639.1 | XRE family transcriptional regulator | - |
| EQH28_RS07320 (EQH28_07745) | - | 1453890..1454840 (+) | 951 | WP_000802056.1 | Abi family protein | - |
| EQH28_RS07325 (EQH28_07750) | - | 1454994..1456121 (+) | 1128 | WP_016397644.1 | site-specific integrase | - |
| EQH28_RS07330 (EQH28_07755) | whiA | 1456209..1457120 (-) | 912 | WP_000011293.1 | DNA-binding protein WhiA | - |
| EQH28_RS07335 (EQH28_07760) | - | 1457117..1458094 (-) | 978 | WP_001231086.1 | YvcK family protein | - |
| EQH28_RS07340 (EQH28_07765) | rapZ | 1458091..1458981 (-) | 891 | WP_000163031.1 | RNase adapter RapZ | - |
| EQH28_RS07345 (EQH28_07770) | - | 1459033..1459413 (-) | 381 | WP_001140412.1 | RidA family protein | - |
| EQH28_RS07350 (EQH28_07775) | yihA | 1459424..1460011 (-) | 588 | WP_000422599.1 | ribosome biogenesis GTP-binding protein YihA/YsxC | - |
| EQH28_RS07355 (EQH28_07780) | clpX | 1460020..1461252 (-) | 1233 | WP_000106346.1 | ATP-dependent Clp protease ATP-binding subunit ClpX | Regulator |
| EQH28_RS07360 (EQH28_07785) | - | 1461284..1461454 (-) | 171 | WP_000442275.1 | hypothetical protein | - |
| EQH28_RS07365 (EQH28_07790) | - | 1461454..1461960 (-) | 507 | WP_000162503.1 | dihydrofolate reductase | - |
| EQH28_RS07370 (EQH28_07795) | - | 1462090..1462608 (-) | 519 | WP_000229874.1 | DNA starvation/stationary phase protection protein | - |
| EQH28_RS07375 (EQH28_07800) | lytC | 1463104..1464609 (-) | 1506 | WP_075271359.1 | choline binding-anchored murein hydrolase LytC | - |
| EQH28_RS07380 (EQH28_07805) | tpiA | 1464647..1465405 (-) | 759 | WP_000087897.1 | triose-phosphate isomerase | - |
| EQH28_RS07385 (EQH28_07810) | - | 1465503..1466180 (-) | 678 | WP_000221604.1 | DnaD domain-containing protein | - |
| EQH28_RS07390 (EQH28_07815) | metA | 1466189..1467133 (-) | 945 | WP_001122713.1 | homoserine O-succinyltransferase | - |
| EQH28_RS07395 (EQH28_07820) | - | 1467315..1467827 (-) | 513 | WP_001049323.1 | adenine phosphoribosyltransferase | - |
| EQH28_RS07400 (EQH28_07825) | - | 1467914..1468672 (-) | 759 | WP_001287234.1 | class I SAM-dependent methyltransferase | - |
| EQH28_RS07405 (EQH28_07830) | - | 1469183..1470313 (-) | 1131 | WP_000229959.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 410 a.a. Molecular weight: 45798.35 Da Isoelectric Point: 4.4550
>NTDB_id=337835 EQH28_RS07355 WP_000106346.1 1460020..1461252(-) (clpX) [Streptococcus pneumoniae strain TVO_1901934]
MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQEIIREELVEEVLADLSEVPKPIELLHILNHYVIGQDR
AKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVR
ILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKETVD
GTDKPILETA
MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQEIIREELVEEVLADLSEVPKPIELLHILNHYVIGQDR
AKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVR
ILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKETVD
GTDKPILETA
Nucleotide
Download Length: 1233 bp
>NTDB_id=337835 EQH28_RS07355 WP_000106346.1 1460020..1461252(-) (clpX) [Streptococcus pneumoniae strain TVO_1901934]
ATGTCTACAAATAGAAAAAATGATATGATGGTTTATTGCTCATTTTGTGGCAAAAACCAAGAAGAAGTACAAAAAATAAT
TGCTGGCAACAATGCTTTTATTTGTAATGAATGCGTGGAGTTAGCTCAGGAAATCATTCGAGAAGAATTGGTTGAGGAAG
TCTTGGCAGACTTGTCTGAGGTGCCAAAACCAATTGAACTCCTCCATATCTTGAACCACTATGTAATTGGTCAAGATCGT
GCCAAGCGTGCCTTGGCAGTGGCGGTTTATAATCACTACAAACGCATCAATTTCCACGATACACGCGAAGAGTCAGAAGA
TGTGGATTTGCAGAAGTCAAACATTTTGATGATTGGCCCAACTGGTTCAGGGAAAACTTTCCTTGCCCAGACCTTGGCTA
AGAGCTTGAATGTGCCTTTTGCTATTGCGGATGCGACAGCTCTGACGGAGGCTGGTTATGTGGGTGAGGATGTGGAAAAT
ATCCTCCTCAAACTCTTGCAGGTTGCTGACTTTAACATCGAACGTGCAGAGCGTGGCATTATCTATGTGGATGAAATTGA
CAAGATTGCCAAGAAGAGTGAGAATGTGTCTATCACACGTGATGTTTCTGGTGAAGGGGTGCAACAAGCCCTTCTCAAGA
TTATCGAGGGAACTGTTGCTAGCGTGCCGCCTCAAGGTGGACGCAAACATCCACAACAAGAGATGATTCAAGTGGATACA
AAAAATATCCTCTTCATCGTGGGTGGTGCTTTTGATGGTATTGAAGAAATTGTCAAACAACGTCTGGGTGAAAAAGTCAT
CGGATTTGGTCAAAACAATAAGGCGATTGACGAAAACAGCTCATACATGCAAGAAATCATCGCTGAAGACATTCAAAAAT
TTGGTATTATCCCTGAGTTGATTGGACGCTTGCCTGTTTTTGCGGCTCTTGAGCAATTGACCGTTGATGACTTGGTTCGC
ATCTTGAAAGAGCCAAGAAATGCCTTGGTGAAACAATACCAAACCTTGCTTTCTTATGATGATGTTGAGTTGGAATTTGA
CGACGAAGCCCTTCAAGAGATTGCTAATAAAGCAATCGAACGGAAGACAGGGGCGCGTGGACTTCGCTCCATTATCGAAG
AAACCATGCTAGATGTTATGTTTGAGGTGCCGAGTCAGGAAAATGTGAAATTGGTTCGCATCACTAAAGAAACTGTTGAT
GGAACGGATAAACCGATCCTAGAAACAGCCTAG
ATGTCTACAAATAGAAAAAATGATATGATGGTTTATTGCTCATTTTGTGGCAAAAACCAAGAAGAAGTACAAAAAATAAT
TGCTGGCAACAATGCTTTTATTTGTAATGAATGCGTGGAGTTAGCTCAGGAAATCATTCGAGAAGAATTGGTTGAGGAAG
TCTTGGCAGACTTGTCTGAGGTGCCAAAACCAATTGAACTCCTCCATATCTTGAACCACTATGTAATTGGTCAAGATCGT
GCCAAGCGTGCCTTGGCAGTGGCGGTTTATAATCACTACAAACGCATCAATTTCCACGATACACGCGAAGAGTCAGAAGA
TGTGGATTTGCAGAAGTCAAACATTTTGATGATTGGCCCAACTGGTTCAGGGAAAACTTTCCTTGCCCAGACCTTGGCTA
AGAGCTTGAATGTGCCTTTTGCTATTGCGGATGCGACAGCTCTGACGGAGGCTGGTTATGTGGGTGAGGATGTGGAAAAT
ATCCTCCTCAAACTCTTGCAGGTTGCTGACTTTAACATCGAACGTGCAGAGCGTGGCATTATCTATGTGGATGAAATTGA
CAAGATTGCCAAGAAGAGTGAGAATGTGTCTATCACACGTGATGTTTCTGGTGAAGGGGTGCAACAAGCCCTTCTCAAGA
TTATCGAGGGAACTGTTGCTAGCGTGCCGCCTCAAGGTGGACGCAAACATCCACAACAAGAGATGATTCAAGTGGATACA
AAAAATATCCTCTTCATCGTGGGTGGTGCTTTTGATGGTATTGAAGAAATTGTCAAACAACGTCTGGGTGAAAAAGTCAT
CGGATTTGGTCAAAACAATAAGGCGATTGACGAAAACAGCTCATACATGCAAGAAATCATCGCTGAAGACATTCAAAAAT
TTGGTATTATCCCTGAGTTGATTGGACGCTTGCCTGTTTTTGCGGCTCTTGAGCAATTGACCGTTGATGACTTGGTTCGC
ATCTTGAAAGAGCCAAGAAATGCCTTGGTGAAACAATACCAAACCTTGCTTTCTTATGATGATGTTGAGTTGGAATTTGA
CGACGAAGCCCTTCAAGAGATTGCTAATAAAGCAATCGAACGGAAGACAGGGGCGCGTGGACTTCGCTCCATTATCGAAG
AAACCATGCTAGATGTTATGTTTGAGGTGCCGAGTCAGGAAAATGTGAAATTGGTTCGCATCACTAAAGAAACTGTTGAT
GGAACGGATAAACCGATCCTAGAAACAGCCTAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpX | Streptococcus mutans UA159 |
86.585 |
100 |
0.866 |
| clpX | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
57.214 |
98.049 |
0.561 |