Detailed information NTG0337232

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH37_RS09280
• Genome accession: NZ_CP035243
• Coordinates: 1852311..1853348 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_1901946
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1847311..1858348

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH37_RS09255 (EQH37_09790)	-	1848050..1849381 (-)	1332	WP_000390043.1	hemolysin family protein	-
EQH37_RS09260 (EQH37_09795)	endA	1849672..1850496 (-)	825	WP_001036789.1	DNA-entry nuclease EndA	Machinery gene
EQH37_RS09265 (EQH37_09800)	-	1850535..1850723 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
EQH37_RS09270 (EQH37_09805)	murA	1850716..1851999 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH37_RS09275 (EQH37_09810)	-	1852023..1852253 (-)	231	WP_000250383.1	DUF1146 family protein	-
EQH37_RS09280 (EQH37_09815)	sepM	1852311..1853348 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH37_RS09285 (EQH37_09820)	coaD	1853332..1853820 (-)	489	WP_001280723.1	pantetheine-phosphate adenylyltransferase	-
EQH37_RS09290 (EQH37_09825)	rsmD	1853810..1854349 (-)	540	WP_000706960.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH37_RS09295 (EQH37_09830)	asnA	1854414..1855406 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH37_RS09300 (EQH37_09840)	-	1855518..1856201 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
EQH37_RS09305 (EQH37_09845)	-	1856257..1856997 (-)	741	WP_000152703.1	RNA methyltransferase	-
EQH37_RS09310 (EQH37_09850)	-	1857031..1857309 (+)	279	WP_001174612.1	acylphosphatase	-
EQH37_RS09315 (EQH37_09855)	yidC	1857387..1858313 (+)	927	WP_000835957.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=337232 EQH37_RS09280 WP_000727277.1 1852311..1853348(-) (sepM) [Streptococcus pneumoniae strain TVO_1901946]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=337232 EQH37_RS09280 WP_000727277.1 1852311..1853348(-) (sepM) [Streptococcus pneumoniae strain TVO_1901946]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591