Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   EQH37_RS02020 Genome accession   NZ_CP035243
Coordinates   382480..383169 (+) Length   229 a.a.
NCBI ID   WP_000518008.1    Uniprot ID   A0A0B7KUQ5
Organism   Streptococcus pneumoniae strain TVO_1901946     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 377480..388169
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH37_RS01995 (EQH37_02110) gpsB 377589..377918 (+) 330 WP_000146522.1 cell division regulator GpsB -
  EQH37_RS02005 (EQH37_02120) - 378404..379561 (+) 1158 WP_050123267.1 class I SAM-dependent RNA methyltransferase -
  EQH37_RS02010 (EQH37_02125) mapZ 379574..380968 (+) 1395 WP_054366278.1 mid-cell-anchored protein MapZ -
  EQH37_RS02015 (EQH37_02130) gndA 381044..382468 (+) 1425 WP_000158781.1 NADP-dependent phosphogluconate dehydrogenase -
  EQH37_RS02020 (EQH37_02135) covR 382480..383169 (+) 690 WP_000518008.1 response regulator transcription factor Regulator
  EQH37_RS02025 (EQH37_02140) cbpC 383267..384283 (+) 1017 WP_000771103.1 choline-binding protein CbpC -
  EQH37_RS02030 (EQH37_02145) mvk 384405..385283 (+) 879 WP_000163322.1 mevalonate kinase -
  EQH37_RS02035 (EQH37_02150) mvaD 385265..386218 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  EQH37_RS02040 (EQH37_02155) - 386205..387212 (+) 1008 WP_000562411.1 phosphomevalonate kinase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26914.21 Da        Isoelectric Point: 6.9836

>NTDB_id=337189 EQH37_RS02020 WP_000518008.1 382480..383169(+) (covR) [Streptococcus pneumoniae strain TVO_1901946]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVSYIYKPVFIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=337189 EQH37_RS02020 WP_000518008.1 382480..383169(+) (covR) [Streptococcus pneumoniae strain TVO_1901946]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTTTCCATGGCTCTTCAGACAGACTATGATTTGATTTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGTCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGACTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTTCATACATCTATAAGCCAGTCTTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGCAGTCTGATGAAAGTTC
CAAGGACCTACCGCAATCTTAGGATAGATGTTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAATTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGCCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGATATACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7KUQ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.261

100

0.485
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.522

100

0.467

Multiple sequence alignment