Detailed information NTG0336861

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: EQH43_RS10600
• Genome accession: NZ_CP035237
• Coordinates: 2079357..2080019 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649968.1
• Uniprot ID: A0A098Z9B1
• Organism: Streptococcus pneumoniae strain TVO_Taiwan19F-14
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2074357..2085019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH43_RS10575 (EQH43_11115)	-	2074507..2074773 (-)	267	WP_001278167.1	Veg family protein	-
EQH43_RS10580 (EQH43_11120)	dnaB	2074775..2076127 (-)	1353	WP_000852486.1	replicative DNA helicase	-
EQH43_RS10585 (EQH43_11125)	rplI	2076171..2076623 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
EQH43_RS10590 (EQH43_11130)	-	2076620..2078593 (-)	1974	WP_000715111.1	DHH family phosphoesterase	-
EQH43_RS10595 (EQH43_11135)	hpf	2078729..2079277 (-)	549	WP_000599104.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
EQH43_RS10600 (EQH43_11140)	comFC/cflB	2079357..2080019 (-)	663	WP_000649968.1	ComF family protein	Machinery gene
EQH43_RS10605 (EQH43_11145)	comFA/cflA	2080016..2081314 (-)	1299	WP_000867608.1	DEAD/DEAH box helicase	Machinery gene
EQH43_RS10610 (EQH43_11150)	-	2081370..2082005 (+)	636	WP_000395746.1	YigZ family protein	-
EQH43_RS10615 (EQH43_11155)	cysK	2082290..2083210 (+)	921	WP_000029860.1	cysteine synthase A	-
EQH43_RS10620 (EQH43_11165)	-	2083285..2083823 (-)	539	Protein_2077	transposase	-
EQH43_RS10625 (EQH43_11170)	-	2083796..2084104 (+)	309	Protein_2078	transposase	-
EQH43_RS10630 (EQH43_11175)	tnpB	2084245..2084568 (-)	324	WP_000973416.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25203.05 Da
• Isoelectric Point: 7.7116

>NTDB_id=336861 EQH43_RS10600 WP_000649968.1 2079357..2080019(-) (comFC/cflB) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQFWCKEGVGVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=336861 EQH43_RS10600 WP_000649968.1 2079357..2080019(-) (comFC/cflB) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAATTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTGGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A098Z9B1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae Rx1	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae D39	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae R6	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae TIGR4	99.091	100	0.991
comFC/cflB	Streptococcus mitis SK321	91.364	100	0.914
comFC/cflB	Streptococcus mitis NCTC 12261	90.909	100	0.909