Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | EQH43_RS09070 | Genome accession | NZ_CP035237 |
| Coordinates | 1782781..1783401 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain TVO_Taiwan19F-14 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1771236..1812305 | 1782781..1783401 | within | 0 |
Gene organization within MGE regions
Location: 1771236..1812305
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EQH43_RS09000 (EQH43_09450) | - | 1771533..1772084 (-) | 552 | WP_001111247.1 | hypothetical protein | - |
| EQH43_RS09005 (EQH43_09455) | - | 1772074..1772271 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| EQH43_RS09010 (EQH43_09460) | - | 1772275..1773069 (-) | 795 | WP_001101215.1 | hypothetical protein | - |
| EQH43_RS09015 (EQH43_09465) | - | 1773477..1773902 (-) | 426 | WP_000204068.1 | hypothetical protein | - |
| EQH43_RS09020 (EQH43_09470) | - | 1774031..1774390 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| EQH43_RS09025 (EQH43_09475) | - | 1774436..1774642 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| EQH43_RS09030 (EQH43_09480) | - | 1774629..1774790 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| EQH43_RS09035 (EQH43_09485) | lytA | 1775149..1776105 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| EQH43_RS09040 (EQH43_09490) | - | 1776481..1777851 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| EQH43_RS09045 (EQH43_09500) | recA | 1778158..1779324 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| EQH43_RS09050 (EQH43_09505) | cinA | 1779379..1780635 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| EQH43_RS09055 (EQH43_09510) | brpA | 1780720..1781736 (-) | 1017 | WP_000239278.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| EQH43_RS09060 (EQH43_09515) | - | 1781744..1782262 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| EQH43_RS09065 (EQH43_09520) | tsaE | 1782252..1782695 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| EQH43_RS09070 (EQH43_09525) | comM | 1782781..1783401 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| EQH43_RS09075 (EQH43_09535) | - | 1783707..1784570 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| EQH43_RS10860 (EQH43_09540) | - | 1784761..1784931 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| EQH43_RS09080 (EQH43_09550) | - | 1785333..1785647 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| EQH43_RS09085 (EQH43_09555) | - | 1785663..1786049 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| EQH43_RS09090 (EQH43_09560) | - | 1786078..1787463 (+) | 1386 | WP_000813488.1 | FtsK/SpoIIIE domain-containing protein | - |
| EQH43_RS09095 (EQH43_09565) | - | 1787466..1787618 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| EQH43_RS09100 (EQH43_09570) | mobT | 1787641..1788846 (+) | 1206 | WP_000398284.1 | MobT family relaxase | - |
| EQH43_RS09105 (EQH43_09575) | - | 1788889..1789110 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| EQH43_RS09110 (EQH43_09580) | - | 1789227..1789724 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| EQH43_RS09115 (EQH43_09585) | - | 1789813..1790205 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| EQH43_RS09120 (EQH43_09590) | - | 1790189..1792636 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| EQH43_RS09125 (EQH43_09595) | - | 1792639..1794816 (+) | 2178 | WP_012677156.1 | CD3337/EF1877 family mobilome membrane protein | - |
| EQH43_RS09130 (EQH43_09600) | - | 1794813..1795814 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| EQH43_RS09135 (EQH43_09605) | - | 1795811..1796743 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| EQH43_RS11080 | - | 1797057..1797104 (+) | 48 | Protein_1810 | hypothetical protein | - |
| EQH43_RS09145 (EQH43_09615) | tet(M) | 1797120..1799039 (+) | 1920 | WP_000691729.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| EQH43_RS09150 (EQH43_09625) | - | 1799403..1799648 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| EQH43_RS09155 (EQH43_09630) | - | 1799645..1799980 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| EQH43_RS09160 (EQH43_09635) | - | 1799993..1800361 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| EQH43_RS09165 (EQH43_09640) | - | 1800348..1800647 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| EQH43_RS09170 (EQH43_09645) | msr(D) | 1800765..1802228 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| EQH43_RS09175 (EQH43_09650) | mef(A) | 1802348..1803565 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| EQH43_RS09180 (EQH43_09655) | - | 1803951..1804121 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| EQH43_RS09185 (EQH43_09660) | - | 1804643..1804834 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| EQH43_RS09190 (EQH43_09665) | - | 1804894..1805247 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| EQH43_RS09195 (EQH43_09675) | - | 1805752..1806174 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| EQH43_RS09200 (EQH43_09680) | - | 1806171..1806401 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| EQH43_RS09205 (EQH43_09685) | - | 1806627..1806878 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| EQH43_RS09210 (EQH43_09690) | - | 1806862..1807065 (+) | 204 | WP_000814511.1 | excisionase | - |
| EQH43_RS09215 (EQH43_09695) | - | 1807147..1808364 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| EQH43_RS09220 (EQH43_09705) | - | 1809255..1811270 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| EQH43_RS09225 (EQH43_09710) | - | 1811272..1811904 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=336841 EQH43_RS09070 WP_000839909.1 1782781..1783401(-) (comM) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=336841 EQH43_RS09070 WP_000839909.1 1782781..1783401(-) (comM) [Streptococcus pneumoniae strain TVO_Taiwan19F-14]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |